A single-component multimodal theranostic platform that takes advantage of multiple imaging and therapy techniques may offer improved diagnostic monitoring capabilities and therapeutic efficacies. In this study, through structural tuning, a novel theranostic agent (TSSAM) with aggregation-induced emission (AIE) characteristics, bright second near-infrared (NIR-II) emission, high reactive oxygen species (ROS) generation capability, and excellent photothermal conversion efficiency (40.1%) was developed. TSSAM makes the best use of its excited-state energy and keeps perfect equilibrium between radiative and nonradiative transition to satisfy the needs of both NIR-II fluorescence imaging (FLI)/photoacoustic imaging (PAI)/photothermal imaging (PTI) trimodal imaging and photodynamic therapy (PDT)/photothermal therapy (PTT) synergistic therapy. Further experiments validated the superior imaging quality and tumoricidal activity of TSSAM, in which tumor tissues were completely eradicated and tumor metastasis was effectively inhibited by merely single injection and one-time laser irradiation. Therefore, this research presents a smart multifunctional material holding great promise in both basic research and clinical practice.

中文翻译：

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充分利用激发态能量：基于第二近红外（NIR-II）聚集诱导的发光原（AIEgens）的多模态诊断学系统

利用多种成像和治疗技术的单组分多峰治疗疗法平台可提供改进的诊断监测功能和治疗效果。在这项研究中，通过结构调整，一种具有聚集诱导发射（AIE）特性，明亮的第二近红外（NIR-II）发射，高活性氧（ROS）产生能力和出色的光热特性的新型治疗病物质（TSSAM）开发了转换效率（40.1％）。TSSAM充分利用其激发态能量，并在辐射和非辐射跃迁之间保持完美的平衡，以满足NIR-II荧光成像（FLI）/光声成像（PAI）/光热成像（PTI）三峰成像和光动力学的需求疗法（PDT）/光热疗法（PTT）协同疗法。进一步的实验验证了TSSAM的卓越成像质量和杀伤活性，其中仅一次注射和一次性激光照射就可以完全根除肿瘤组织，并有效抑制肿瘤转移。因此，本研究提出了一种在基础研究和临床实践中都具有广阔前景的智能多功能材料。