Abstract A global sensitivity analysis of a multiscale computational model of microvascular flow is presented. A total of 140 simulations have been completed and analyzed varying 6 input parameters and considering their effects on 7 output variables. Interestingly, the vascular network topology has been found as a determinant factor for both vasculature-related and interstitium-related quantities. Regarding the firsts, the vascular network topology has obtained a score of 5.5/6 and 6/6 for average and spatial distribution respectively (where 6 is the maximum and 1 is the minimum). On the other hand, considering interstitium-related quantities, the score is 4/6 and 5/6 for average and spatial distribution respectively. These results suggest that the network topology has a significant influence on the outcome of the computational analysis.

中文翻译：

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一种应用于微血管流动多尺度模型的全局敏感性分析方法

摘要 提出了微血管流动多尺度计算模型的全局敏感性分析。总共完成了 140 次模拟，分析了不同的 6 个输入参数，并考虑了它们对 7 个输出变量的影响。有趣的是，血管网络拓扑结构已被发现是血管相关和间质相关数量的决定因素。关于第一，血管网络拓扑的平均和空间分布分别获得了 5.5/6 和 6/6 的分数（其中 6 是最大值，1 是最小值）。另一方面，考虑到与间隙相关的数量，平均和空间分布的得分分别为 4/6 和 5/6。这些结果表明网络拓扑对计算分析的结果有显着影响。