Abstract

Background

The global prevalence of metabolic syndrome (MS) is increasing due to lifestyle changes. Studies have found that MS is associated with human immunodeficiency virus (HIV) and antiretroviral treatment (ART), but controversies still exist on associations between HIV and MS.

Aims

To assess associations between HIV and MS among ART-naïve HIV positive individuals compared to HIV negative individuals.

Subjects and methods

A cross-sectional study among ART-naïve HIV positive and HIV negative individuals recruited from HIV treatment and testing facilities in Ethiopia. Information was collected on components of MS: waist circumference, triglycerides, high-density lipoprotein cholesterol (HDL-C), blood pressure and fasting plasma glucose (FPG). Data were analysed using logistic and linear regression stratified by sex and adjusted for age, wealth and education.

Results

Data from 329 HIV positive and 100 HIV negative individuals were included. HIV positive status was associated with higher odds of MS in women (OR: 3.56, 95%CI: 1.25; 10.15) (n = 292), but not in men (OR: 0.98, 95%CI: 0.22; 4.30) (n = 137), interaction: p= .11. Associations between HIV and components of MS were strongest for HDL-C among women and for FPG among men. The most prevalent components of MS in HIV positive individuals were elevated triglycerides, reduced HDL-C and elevated FPG.

Conclusions

HIV was associated with MS among ART-naïve women, suggesting that MS should be evaluated before initiating ART and monitored during treatment to identify those at risk of developing diabetes and cardiovascular disease (CVD).

中文翻译：

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埃塞俄比亚人口中的HIV和代谢综合征。

摘要

背景

由于生活方式的改变，新陈代谢综合症（MS）的全球患病率正在增加。研究发现，MS与人类免疫缺陷病毒（HIV）和抗逆转录病毒治疗（ART）有关，但在HIV与MS之间的关联方面仍存在争议。

目的

为了评估与未感染HIV的个体相比，未接受过ART感染的HIV阳性个体中HIV与MS之间的关联。

主题与方法

从埃塞俄比亚的艾滋病毒治疗和测试机构招募的未接受过抗病毒治疗的艾滋病毒阳性和艾滋病毒阴性个体的横断面研究。收集了有关MS成分的信息：腰围，甘油三酸酯，高密度脂蛋白胆固醇（HDL-C），血压和空腹血糖（FPG）。使用按性别分层并根据年龄，财富和教育程度进行调整的逻辑和线性回归分析数据。

结果

包括来自329名HIV阳性者和100名HIV阴性者的数据。女性HIV阳性与MS患病几率更高（OR：3.56，95％CI：1.25; 10.15）（n  = 292），而与男性无关（OR：0.98，95％CI：0.22; 4.30）（n  = 137），互动：p = .11。在女性中，HDL-C和男性中的FPG之间，HIV与MS成分之间的关​​联最强。在HIV阳性个体中，MS最普遍的成分是甘油三酯升高，HDL-C降低和FPG升高。

结论

HIV与未接受过抗逆转录病毒治疗的女性中的MS有关，建议在开始抗逆转录病毒治疗之前应先评估MS，并在治疗过程中对其进行监测，以发现有患糖尿病和心血管疾病（CVD）危险的人群。