Abstract

It is critical to incorporate additional information of parameters into the simultaneous estimation process. In this paper, we propose a new confidence method that utilizes the information on parameter priority and keeps the elegance and simplicity of Holm’s weighted testing procedure. The new method is grounded on the method of random partitions, in conjunction with probability inequalities, to ensure the control of the simultaneous confidence level. Simulation studies show significant power improvements for appropriately assigned weights. The new confidence method casts new lights on differential gene expression among mutant genes that are associated with BRCA1 and BRCA2 proteins in the DNA repair process.

摘要

将参数的附加信息纳入同步估计过程至关重要。在本文中，我们提出了一种新的置信度方法，该方法利用了参数优先级的信息，并保持了 Holm 加权测试过程的优雅和简单。新方法以随机分区方法为基础，结合概率不等式，确保对同时置信水平的控制。模拟研究表明，适当分配的权重可显着提高功率。新的置信度方法为 DNA 修复过程中与 BRCA1 和 BRCA2 蛋白相关的突变基因之间的差异基因表达提供了新的视角。