The advantages and emergent interest in organism-derived bioactive molecules have recently renewed scientific research attention in this field. Since 1967, about 52 different derivatives of phthalate ester (PE) have been reported from different taxonomic groups. Anthropogenic derivatives of the PEs are confined to petroleum products, as a plasticizer. These derivatives exhibit a potential toxicity on the living system, particularly those having a reduced molecular weight. An organism-derived PE differs chemically from that of synthetic ones in terms of the abundance of ¹⁴C and its bond structure, leading to its varied activities in the biological system. The study of the biosynthetic pathway and the optimization of parameters for product enhancement have advocated their organism-derived nature. Various bioactivities of such organisms-derived derivatives of phthalates such as antibacterial, antifungal, an inducer of apoptosis and cell cycle arrest, antioxidant, cytotoxic, antitumor, allopathic, larvicidal, antifouling, chemotactic, antimelanogenic, antiviral, and anti-inflammatory activities have been well documented. This is the first review that focuses on the positive bioactivities of such organism-derived PEs in detail. There is enormous scope for research in this field to search for the utilization of such organism-derived phthalate derivatives will have potential bioactivity, their possible use to improve their efficacy.

在生物来源的生物活性分子中的优点和兴起的兴趣近来已经重新引起了该领域的科学研究关注。自1967年以来，已经报道了来自不同分类学组的大约52种邻苯二甲酸酯（PE）衍生物。PE的人为衍生物仅限于石油产品，作为增塑剂。这些衍生物对生命系统，特别是分子量降低的那些，表现出潜在的毒性。生物源PE的化学成分与合成PE的化学成分不同之处在于¹⁴C及其键结构，导致其在生物系统中的各种活动。生物合成途径的研究和产物增强参数的优化主张了它们的生物来源性质。这类生物衍生的邻苯二甲酸酯衍生物具有多种生物活性，例如抗菌，抗真菌，细胞凋亡和细胞周期阻滞诱导剂，抗氧化剂，细胞毒性，抗肿瘤，同种异体，幼虫，抗污垢，趋化作用，促产褥疮，抗病毒和抗炎活性。有据可查。这是第一篇详细论述此类生物衍生PE的积极生物活性的综述。该领域的研究范围很大，以搜寻利用这种生物源的邻苯二甲酸酯衍生物具有潜在的生物活性，