Neurodegenerative disease is a kind of chronic, progressive nervous system disease characterized by neuron degeneration or apoptosis. Current treatments cannot prevent the development of the disease. Possible alternative treatments include cell therapy, especially with the use of mesenchymal stem cells (MSCs). MSCs are pluripotent stem cells with capacities for self-renewal and multidirectional differentiation. MSCs may serve as a reliable source of neural cells for potential cell replacement therapy or regenerative medicine treatment. Here, we summarized the therapeutic mechanisms of MSCs and how they can contribute to the development of treatments for neurodegenerative diseases.

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间充质干细胞：神经退行性疾病的潜在治疗策略

神经退行性疾病是一种以神经元变性或凋亡为特征的慢性进行性神经系统疾病。目前的治疗方法不能阻止疾病的发展。可能的替代疗法包括细胞疗法，尤其是使用间充质干细胞 (MSC)。间充质干细胞是具有自我更新和多向分化能力的多能干细胞。间充质干细胞可作为潜在的细胞替代疗法或再生医学治疗的可靠神经细胞来源。在这里，我们总结了 MSCs 的治疗机制以及它们如何促进神经退行性疾病治疗的发展。