Parkinson’s disease (PD) is a common neurodegenerative disorder; however, well-established biochemical markers have not yet been identified. This review article covers several candidate cerebrospinal fluid (CSF) biomarkers for PD based on the recent literature and meta-analysis data. The decrease of α-synuclein in PD is supported by meta-analyses with modest reproducibility, and a decrease of amyloid β42 is seen as a prognostic marker for cognitive decline. Tau, phosphorylated tau (p-tau), and neurofilament light chains have been used to discriminate PD from other neurodegenerative disorders. This article also describes more hopeful biochemical markers, such as neurotransmitters, oxidative stress markers, and other candidate biomarkers.

中文翻译：

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帕金森氏病中的脑脊髓液生物标志物：文献和荟萃分析的重要概述。

帕金森氏病（PD）是常见的神经退行性疾病；但是，尚未确定完善的生化标记。这篇综述文章根据最近的文献和荟萃分析数据，涵盖了PD的几种候选脑脊液（CSF）生物标志物。PD的α-突触核蛋白的减少得到了具有适度可重复性的荟萃分析的支持，而淀粉样蛋白β42的减少被认为是认知能力下降的预后标志。Tau，磷酸化tau（p-tau）和神经丝轻链已被用于区分PD与其他神经退行性疾病。本文还介绍了更有希望的生化标记，例如神经递质，氧化应激标记和其他候选生物标记。