In this work ion functionalized hydrogels as potent drug delivery systems are presented. The ion functionalization of the hydrogel enables the retention of ionic drug molecules and thus a reduction of burst release effects. Timolol maleate in combination with polymerized anionic 3‐sulfopropylmethacrylate potassium and ibuprofen combined with cationic poly‐[2‐(methacryloyloxy)ethyl] trimethylammonium chloride are investigated in respect to their drug release profile. The results are showing an ion exchange depending release behavior instead of a diffusion‐controlled drug release as it is known from common drug delivery systems. Furthermore, the suitability of such hydrogels for standard methods for sterilization is investigated.

中文翻译：

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离子交换控制聚合离子液体的药物释放。

在这项工作中，离子功能化水凝胶作为有效的药物递送系统被提出。水凝胶的离子功能化能够保留离子药物分子，从而降低突释效应。研究了马来酸噻吗洛尔与聚合的阴离子 3-磺丙基甲基丙烯酸酯钾和布洛芬与阳离子聚-[2-(甲基丙烯酰氧基)乙基]三甲基氯化铵的组合，研究它们的药物释放曲线。结果显示出依赖于离子交换的释放行为，而不是常见药物递送系统中已知的扩散控制药物释放。此外，研究了这种水凝胶对标准灭菌方法的适用性。