Front Cover: The authors conducted research on antimicrobial polymer structure‐activity relationships (SARs) based on their platform of guanidine containing aliphatic biodegradable polycarbonates with varying amphiphilicity and charge densities. These guanidinylated polycarbonates exhibited potent antimicrobial activity, but with low hemolytic activity. Furthermore, these polymers exhibited the ability to self‐assemble and present micelle‐like nanostructure due to their intrinsic amphiphilic macromolecular structure. This cover art depicts the antimicrobial polymer strands and their aggregation as nanoparticles in an aqueous environment, and the polymer micelles contacting the microbes in suspension, causing the membrane disruption that is the basis of the antimicrobial properties. This is reported by Chloe A. Cho, Chao Liang, Janesha Perera, Margaret A. Brimble, Simon Swift, Jianyong Jin in article 2000065.

中文翻译：

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通过延长间隔臂和胶束自组装的长度，具有增强的抗菌活性的胍基化两亲聚碳酸酯

封面：作者基于含胍的脂肪族可生物降解聚碳酸酯的两亲和电荷密度不同的平台，对抗菌聚合物的结构活性关系（SAR）进行了研究。这些胍基化聚碳酸酯显示出有效的抗菌活性，但溶血活性低。此外，这些聚合物由于其固有的两亲大分子结构而具有自组装和呈现胶束状纳米结构的能力。该覆盖技术描述了抗微生物聚合物链及其在水性环境中作为纳米颗粒的聚集，并且聚合物胶束以悬浮状态接触微生物，从而引起了作为抗微生物特性基础的膜破裂。这是由Chloe A. Cho，Chao Liang，Janesha Perera和Margaret A所报道的。