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Cannabis use in patients with early psychosis is associated with alterations in putamen and thalamic shape.
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-07-20 , DOI: 10.1002/hbm.25131 Musa Sami 1 , James H Cole 1 , Matthew J Kempton 1 , Luciano Annibale 1 , Debasis Das 2 , Marlene Kelbrick 3 , Savitha Eranti 4 , Tracy Collier 1 , Chidimma Onyejiaka 5 , Aisling O'Neill 1 , David J Lythgoe 1 , Philip McGuire 1 , Steve C R Williams 1 , Sagnik Bhattacharyya 1
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-07-20 , DOI: 10.1002/hbm.25131 Musa Sami 1 , James H Cole 1 , Matthew J Kempton 1 , Luciano Annibale 1 , Debasis Das 2 , Marlene Kelbrick 3 , Savitha Eranti 4 , Tracy Collier 1 , Chidimma Onyejiaka 5 , Aisling O'Neill 1 , David J Lythgoe 1 , Philip McGuire 1 , Steve C R Williams 1 , Sagnik Bhattacharyya 1
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Around half of patients with early psychosis have a history of cannabis use. We aimed to determine if there are neurobiological differences in these the subgroups of persons with psychosis with and without a history of cannabis use. We expected to see regional deflations in hippocampus as a neurotoxic effect and regional inflations in striatal regions implicated in addictive processes. Volumetric, T1w MRIs were acquired from people with a diagnosis psychosis with (PwP + C = 28) or without (PwP − C = 26) a history of cannabis use; and Controls with (C + C = 16) or without (C − C = 22) cannabis use. We undertook vertex‐based shape analysis of the brainstem, amygdala, hippocampus, globus pallidus, nucleus accumbens, caudate, putamen, thalamus using FSL FIRST. Clusters were defined through Threshold Free Cluster Enhancement and Family Wise Error was set at p < .05. We adjusted analyses for age, sex, tobacco and alcohol use. The putamen (bilaterally) and the right thalamus showed regional enlargement in PwP + C versus PwP − C. There were no areas of regional deflation. There were no significant differences between C + C and C − C. Cannabis use in participants with psychosis is associated with morphological alterations in subcortical structures. Putamen and thalamic enlargement may be related to compulsivity in patients with a history of cannabis use.
中文翻译：
早期精神病患者吸食大麻与壳核和丘脑形状的改变有关。
大约一半的早期精神病患者有大麻使用史。我们的目的是确定这些有或没有大麻使用史的精神病患者亚组是否存在神经生物学差异。我们预计海马体的区域性紧缩是一种神经毒性效应，而纹状体区域的区域性膨胀则与成瘾过程有关。体积 T1w MRI 是从诊断为精神病且有 (PwP + C = 28) 或没有 (PwP − C = 26) 大麻使用史的人获得的；控制使用（C + C = 16）或不使用（C − C = 22）大麻。我们使用 FSL FIRST 对脑干、杏仁核、海马、苍白球、伏核、尾状核、壳核、丘脑进行了基于顶点的形状分析。聚类通过无阈值聚类增强来定义，并且 Family Wise Error 设置为p < .05。我们调整了年龄、性别、吸烟和饮酒的分析。壳核（双侧）和右侧丘脑在 PwP + C 与 PwP − C 中显示区域增大。没有区域收缩的区域。 C + C 和 C − C 之间没有显着差异。精神病参与者的大麻使用与皮质下结构的形态改变有关。壳核和丘脑增大可能与有大麻使用史的患者的强迫症有关。
更新日期：2020-09-21
中文翻译：
早期精神病患者吸食大麻与壳核和丘脑形状的改变有关。
大约一半的早期精神病患者有大麻使用史。我们的目的是确定这些有或没有大麻使用史的精神病患者亚组是否存在神经生物学差异。我们预计海马体的区域性紧缩是一种神经毒性效应，而纹状体区域的区域性膨胀则与成瘾过程有关。体积 T1w MRI 是从诊断为精神病且有 (PwP + C = 28) 或没有 (PwP − C = 26) 大麻使用史的人获得的；控制使用（C + C = 16）或不使用（C − C = 22）大麻。我们使用 FSL FIRST 对脑干、杏仁核、海马、苍白球、伏核、尾状核、壳核、丘脑进行了基于顶点的形状分析。聚类通过无阈值聚类增强来定义，并且 Family Wise Error 设置为p < .05。我们调整了年龄、性别、吸烟和饮酒的分析。壳核（双侧）和右侧丘脑在 PwP + C 与 PwP − C 中显示区域增大。没有区域收缩的区域。 C + C 和 C − C 之间没有显着差异。精神病参与者的大麻使用与皮质下结构的形态改变有关。壳核和丘脑增大可能与有大麻使用史的患者的强迫症有关。
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