New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment‐Derived Fungus Epicoccum nigrum SD‐388,Chemistry & Biodiversity

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New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment‐Derived Fungus Epicoccum nigrum SD‐388
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-07-20 , DOI: 10.1002/cbdv.202000320
Lu-Ping Chi _{1,

2,

3} , Xiao-Ming Li _{1,

2} , Xin Li _{1,

2} , Bin-Gui Wang _{1,

2,

4}

Affiliation

Two new antibacterial thiodiketopiperazine derivatives (TDKPs), 7-dehydroxyepicoccin H and 7-hydroxyeutypellazine F, along with seven known TDKP analogs, were isolated and identified from Epicoccum nigrum SD-388, a deep-sea-sediment-derived fungus. The structures of these compounds were elucidated on the basis of detailed spectroscopic analysis. The absolute configuration of 7-dehydroxyepicoccin H was established by X-ray crystallographic analysis, while 7-hydroxyeutypellazine F was determined by ECD experiment and TDDFT-ECD calculation. The antibacterial activities against human and aquatic pathogens were evaluated. 7-Dehydroxyepicoccin H and 7-hydroxyeutypellazine F displayed inhibitory activities against aquatic pathogens Vibrio vulnificus, V. alginolyticus, and Edwardsiella tarda, with MIC values ranging from 4.0 to 8.0 μg/mL.

中文翻译：

来自深海沉积物衍生真菌 Epicoccum nigrum SD-388 的新型抗菌硫代二酮哌嗪

从深海沉积物衍生的真菌 Epicoccum nigrum SD-388 中分离并鉴定了两种新的抗菌硫代二酮哌嗪衍生物 (TDKP)、7-脱羟基表球菌素 H 和 7-羟基异辛基紫杉醇 F，以及七种已知的 TDKP 类似物。在详细的光谱分析的基础上阐明了这些化合物的结构。7-脱羟基表球菌素H的绝对构型通过X射线晶体学分析确定，而7-羟基eutypellazine F通过ECD实验和TDDFT-ECD计算确定。评价了对人类和水生病原体的抗菌活性。7-脱羟基表球菌素 H 和 7-羟基eutypellazine F 显示出对水生病原体创伤弧菌、溶藻弧菌和迟发爱德华氏菌的抑制活性，MIC 值范围为 4.0 至 8.0 μg/mL。

更新日期：2020-07-20

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