Abstract

A series of N-(4-oxoadamantan-1-yl)-N′-[fluoro(chloro)phenyl]ureas have been synthesized in 27–73% yields by reaction of 1-isocyanatoadamantan-4-one with fluoro- and chlorosubstituted anilines. The products are promising as human soluble epoxide hydrolase inhibitors.

中文翻译：

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含多环片段的N，N'-双取代尿素及其等规类似物的合成与性能：II。N-（4-氧金刚烷-1-基）-N'-[氟（氯）苯基]脲

摘要

通过1-异氰酸根合金刚烷-4-酮与氟代和氯代取代基的反应，已合成了一系列N-（4-氧代金刚烷-1-基）-N '-[氟（氯）苯基]脲，产率为27-73％。苯胺。该产品有望作为人类可溶性环氧水解酶抑制剂。