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Reformatsky Reaction of Methyl 1-Bromocyclohexanecarboxylate with N , N ′-(1,4-Phenylene)bis(1-arylmethanimines)
Russian Journal of Organic Chemistry ( IF 0.8 ) Pub Date : 2020-07-20 , DOI: 10.1134/s107042802006010x E. A. Nikiforova , D. V. Baibarodskikh , N. F. Kirillov , L. A. Glavatskikh
中文翻译:
1-溴环己烷甲酸甲酯与N,N'-(1,4-亚苯基)双(1-芳基甲亚胺)的Reformatsky反应
更新日期:2020-07-20
Russian Journal of Organic Chemistry ( IF 0.8 ) Pub Date : 2020-07-20 , DOI: 10.1134/s107042802006010x E. A. Nikiforova , D. V. Baibarodskikh , N. F. Kirillov , L. A. Glavatskikh
Abstract
Reformatsky reagent prepared from methyl 1-bromocyclohexanecarboxylate reacted with N,N′-(1,4-phenylene)bis(1-arylmethanimines) to produce 2,2′-(1,4-phenylene)bis[3-aryl-2-azaspiro[3.5]nonan-1-ones] as a result of successive nucleophilic additions to the C=N double bonds of the substrate and intramolecular cyclization of the corresponding intermediates. The stepwise reaction mechanism was proved by the isolation of 2-[4-(arylmethylideneamino)phenyl]-3-aryl-2-azaspiro[3.5]nonan-1-ones in the reactions with equimolar amounts of the Schiff base and Reformatsky reagent.中文翻译:
1-溴环己烷甲酸甲酯与N,N'-(1,4-亚苯基)双(1-芳基甲亚胺)的Reformatsky反应