The nucleophilic ring-opening reaction of tetrahydropyran derivative of the closo-dode-caborate dianion with sodium azide in the presence of tetrabutylammonium bromide led to the novel azido-derivatives of[B12H12]2−. A Cu-catalyzed 1,3-dipolar [3+2] cycloaddition reaction of the closo-dodecaborate dianion azido-derivatives with alkynyl-cholesterol led to 1,4-disubstituted 1,2,3-triazoles with the closo-dodecaborate fragment at position 1. The resulting conjugates are potentially suitable for the development of liposomal drugs to selectively deliver boron into a tumor cell for boron neutron capture therapy of cancer.

中文翻译：

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使用“点击”反应合成接近十二硼酸二价阴离子与胆固醇的结合物

在四丁基溴化铵的存在下，四氢吡喃衍生物与叠氮化钠的亲核开环反应产生了[B12H12]2-的新型叠氮衍生物。Cu 催化的 1,3-偶极 [3+2] 环加成反应生成 1,4-二取代的 1,2,3-三唑和 closo-ddecaborate 片段位置 1. 所得结合物可能适用于开发脂质体药物，以选择性地将硼输送到肿瘤细胞中，用于癌症的硼中子俘获疗法。