Lung carcinogenesis is one of the main sources of cancer-related mortality globally and it is estimated that nearly 1 million people die from it every year. The 5-year survival rate of lung carcinogenesis is reported at just 15%. The aim of the current research was to investigate the immunomodulatory effect of eriocitrin against benzo(a)pyrene [B(a) P]-induced lung tumorigenesis in Swiss albino mice. The lung sarcoma was provoked through oral gavage of B(a)P (50 mg/kg body weight) two times/week for four weeks. CEA, lung weight, lipid peroxidation (LPO), body weight, immuno-globulin (IgG, IgA, and IgM), tumor incidence, serum marker enzymes (LDH, AHH, λ-GT, and 5'-NTs), hematological counts (leucocytes, lymphocytes, neutrophils, absolute numbers of lymphocytes and neutrophils), antioxidants (SOD and CAT), inflammatory modulators (IL-1β, IL-6, and TNF-α), immune complexes (avidity index, phagocyte index, NBT reduction, and SIC) and histopathological changes were analyzed. Moreover, the status of apoptosis proteins (Bax, caspase-9, and caspase-3) and cell proliferative protein (cyclin D1 and cyclin A) expression was determined by Western blot and PCNA by immunohistochemical analysis. B(a)P-challenged cancer-bearing mice exhibited augmented levels of lipid peroxidation, tumor incidence, lung weight, CEA, serum marker enzymes, IgA, SIC, cell proliferative markers, and inflammatory cytokines with concurrent decrease in body weight, antioxidant levels, hematological counts, immunoglobulins, immune complexes, and apoptotic protein expression. The eriocitrin treatments caused significant reversion of all these marker to previous levels. Overall, the results propose the immunomodulatory prospective of eriocitrin against B(a) P-induced lung carcinogenesis on Swiss albino mice.

中文翻译：

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Eriocitrin在苯并（a）induced诱导的肺癌发生实验动物中的免疫调节作用。

肺癌的致癌作用是全球范围内与癌症相关的死亡率的主要来源之一，据估计每年有近100万人死于肺癌。据报道，肺癌致癌物的5年生存率仅为15％。当前研究的目的是研究瑞士柠檬白蛋白对瑞士白化病小鼠中苯并（a）[[B（a）P]诱导的肺肿瘤发生的免疫调节作用。每周两次口服B（a）P（50 mg / kg体重）两次，引起肺肉瘤，持续4周。CEA，肺重量，脂质过氧化（LPO），体重，免疫球蛋白（IgG，IgA和IgM），肿瘤发生率，血清标志物酶（LDH，AHH，λ-GT和5'-NTs），血液学计数（白细胞，淋巴细胞，中性粒细胞，淋巴细胞和中性粒细胞的绝对数量），抗氧化剂（SOD和CAT），炎性调节剂（IL-1β，IL-6，和TNF-α），免疫复合物（亲和力指数，吞噬细胞指数，NBT降低和SIC）和组织病理学变化进行了分析。此外，通过免疫印迹和PCNA通过免疫组织化学分析确定凋亡蛋白（Bax，caspase-9和caspase-3）和细胞增殖蛋白（cyclin D1和cyclin A）的表达状态。B（a）P致癌的小鼠表现出脂质过氧化，肿瘤发生率，肺重量，CEA，血清标志物酶，IgA，SIC，细胞增殖标志物和炎性细胞因子水平升高，同时体重，抗氧化剂水平降低，血液学计数，免疫球蛋白，免疫复合物和凋亡蛋白表达。eriocitrin治疗导致所有这些标记物显着回复至先前水平。总体，