T lymphocytes undergo carefully orchestrated programming during development in the thymus and subsequently during differentiation in the periphery. This intricate specification allows for cell-type and context-specific transcriptional programs that regulate immune responses to infection and malignancy. Epigenetic changes, including histone modifications and covalent modification of DNA itself through DNA methylation, are now recognized to play a critical role in these cell-fate decisions. DNA methylation is mediated primarily by the actions of the DNA methyltransferase (DNMT) and ten-eleven-translocation (TET) families of epigenetic enzymes. In this review, we discuss the role of DNA methylation and its enzymatic regulators in directing the development and differentiation of CD4⁺ and CD8⁺ T-cells.

中文翻译：

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T 细胞发育和分化中的 DNA 甲基化。

T 淋巴细胞在胸腺发育期间以及随后在外周分化期间经历精心编排的编程。这种复杂的规范允许调节对感染和恶性肿瘤的免疫反应的细胞类型和特定环境的转录程序。表观遗传变化，包括组蛋白修饰和通过 DNA 甲基化对 DNA 本身进行共价修饰，现在被认为在这些细胞命运决定中发挥关键作用。DNA 甲基化主要由 DNA 甲基转移酶 (DNMT) 和表观遗传酶的 10-11 易位 (TET) 家族的作用介导。在这篇综述中，我们讨论了 DNA 甲基化及其酶调节剂在指导 CD4 ⁺和 CD8 ^{+的发育和分化中的作用}T细胞。