Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder which its prevalence directly depends on the diagnostic criteria used to define this syndrome. Recently, many different factors have been introduced as predisposing factors in the high incidence of PCOS, one of them is microRNAs. MicroRNAs are short non-coding RNAs that can regulate target gene expression through transcriptional repression or degradation. So, they can play an important role in the control of reproductive and endocrine functions, tissue development and differentiation particularly the process of oocyte maturation, folliculogenesis and efficient fertilization. MicroRNAs are involved in metabolic processes and influenced by obesity and high androgen concentrations in PCOS patients. Abnormal expression of miRNAs may associate with several reproductive disorders including PCOS. In addition, microRNAs can be used as a biomarker to differentiate between PCOS patients and women with normal menstruation. The aim of this review is to investigate the association between PCOS signaling pathways and miRNAs expression.

中文翻译：

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多囊卵巢综合征中miRNA表达与氧化应激信号通路之间的关联。

多囊卵巢综合征（PCOS）是一种异质性内分泌疾病，其患病率直接取决于用于定义该综合征的诊断标准。最近，已引入许多不同的因素作为PCOS高发的诱因，其中之一就是microRNA。MicroRNA是短的非编码RNA，可以通过转录抑制或降解来调节靶基因的表达。因此，它们在控制生殖和内分泌功能，组织发育和分化，特别是卵母细胞成熟，卵泡形成和有效受精的过程中起重要作用。MicroRNA与PCOS患者的肥胖症和雄激素浓度高有关，参与代谢过程。miRNA的异常表达可能与包括PCOS在内的几种生殖疾病有关。此外，microRNA可用作生物标记物，以区分PCOS患者和月经正常的女性。这篇综述的目的是研究PCOS信号通路与miRNA表达之间的联系。