Every year, approximately 100 million individuals are infected with dengue viral infections. Severe dengue infection, characterized as dengue hemorrhagic fever, leads to loss of intravascular fluids and severe bleeding. During dengue virus (DENV) secondary infection, the body produces neutralizing antibodies that cause a strong immune response, resulting in severe hemolysis and plasma leakage. DENV infections in humans stimulate production of virus serotype-specific and cross-reactive antibodies. The envelope (E) protein of DENV contains potent antigenic sites, with one known as E protein domain III (EDIII). Studies of DENV EDIII in mouse models have shown that strongly neutralizing mouse monoclonal antibodies (mAbs) are DENV-serotype specific and bind to an epitope on EDIII that is unique to each serotype. Unlike DENV-serotype-specific mouse mAbs, cross-reactive mAbs that bind to EDIII have moderate-to-weak neutralizing activity. Studies with mouse mAbs resulted in identification and mapping of different epitopes on the lateral ridge of DENV EDIII.

中文翻译：

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登革热病毒包膜蛋白域III抗体在登革热病毒感染中的反常作用。

每年大约有1亿个人感染登革热病毒感染。严重的登革热感染（特征为登革热出血热）导致血管内积液丢失和严重出血。在登革热病毒（DENV）继发感染期间，人体会产生中和抗体，从而引起强烈的免疫反应，从而导致严重的溶血和血浆渗漏。人的DENV感染会刺激病毒血清型特异性和交叉反应性抗体的产生。DENV的包膜（E）蛋白包含有效的抗原位点，其中一个被称为E蛋白结构域III（EDIII）。DENV EDIII在小鼠模型中的研究表明，强中和性小鼠单克隆抗体（mAb）具有DENV血清型特异性，并结合每种血清型所独有的EDIII表位。与DENV血清型特异性小鼠单克隆抗体不同，与EDIII结合的交叉反应mAb具有中度至弱度的中和活性。小鼠mAb的研究导致DENV EDIII侧脊上不同表位的鉴定和定位。