This article serves to evaluate the association of polymorphisms of mismatch repair genes (hMLH1 and hMSH2) with breast cancer (BC) susceptibility through a meta-analysis. Our methods involved extensive research in Chinese and English databases that examined the association of hMLH1 and hMSH2 polymorphisms with susceptibility to BC, strictly abiding by established inclusion and exclusion criteria. Software Stata 12.0 was used for statistical data analysis. A total of 12 studies were available for meta-analysis, published between 2014 and 2017, of which respectively 9 studies explored the association of hMLH1 (rs1799977 A > G and rs63750447 T > A) and 3 studies explored the association of hMSH2 (rs4987188 [Gly322Asp] and rs17217772 [Asn127Ser]) with patients' susceptibility to BC. The results showed that both the rs1799977 A > G polymorphism GA + GG genotype (especially in the Caucasian population) and the rs63750447 T > A polymorphism TA + AA genotype in the hMLH1 gene increased patients' susceptibility to BC. The genotype detection method was selected as a target for subgroup analysis. According to studies where MassARRAY assay was conducted, the rs1799977 A > G polymorphism was correlated with BC susceptibility in the dominant model, while rs4987188 (Gly322Asp) and rs17217772 (Asn127Ser) of the hMSH2 gene presented no observable correlation with the risk for BC. Both the rs1799977 A > G and rs63750447 T > A polymorphisms in the hMLH1 gene showed a significant association with a markedly increased risk for BC, while rs4987188 (Gly322Asp) and rs17217772 (Asn127Ser) of the hMSH2 gene were not clearly correlated with BC susceptibility.

中文翻译：

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错配修复基因hMLHI和hMSH2多态性与乳腺癌易感性的关联：一项荟萃分析。

本文旨在通过荟萃分析评估错配修复基因（hMLH1和hMSH2）的多态性与乳腺癌（BC）易感性的关系。我们的方法涉及在中文和英文数据库中进行的广泛研究，这些数据库检查了hMLH1和hMSH2多态性与BC易感性的关系，严格遵守既定的纳入和排除标准。使用Stata 12.0软件进行统计数据分析。共有12项研究可供荟萃分析，于2014年至2017年发表，其中9项研究探讨了hMLH1的关联（rs1799977 A> G和rs63750447 T> A），还有3项研究探讨了hMSH2的关联（rs4987188 [ [Gly322Asp]和rs17217772 [Asn127Ser]）患者对BC的易感性。结果表明，rs1799977 A> G多态性GA + GG基因型（尤其是白种人）和rs63750447 T> hMLH1基因多态性TA + AA基因型增加了患者对BC的易感性。选择基因型检测方法作为亚组分析的目标。根据进行MassARRAY分析的研究，在优势模型中rs1799977 A> G多态性与BC易感性相关，而hMSH2基因的rs4987188（Gly322Asp）和rs17217772（Asn127Ser）与BC风险没有可观察到的相关性。hMLH1基因的rs1799977 A> G和rs63750447 T> A的多态性均与BC风险显着相关，而hMSH2基因的rs4987188（Gly322Asp）和rs17217772（Asn127Ser）与BC易感性没有明显关联。