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Qualitative theoretical modeling to study the possibility of detecting multi-virus in blood flow using Nano-quartz crystal microbalance
Mathematical Biosciences and Engineering Pub Date : 2020-06-29 , DOI: 10.3934/mbe.2020252
Mohamed Abbas 1, 2 , Ali Algahtani 3, 4 , Amir Kessentini 3, 5, 6 , Hassen Loukil 1, 7 , Muneer Parayangat 1 , Thafasal Ijyas 1 , Abdul Wase Mohammed 1
Affiliation  

Methods for testing the presence of a virus in the blood are of interest to researchers and doctors because they determine how rapidly a virus is detected. In general, virus detection is a major scientific problem due to the serious effects of viruses on the human body. At present, only one virus can be detected in a single test. This potentially costs the medical establishment more time and money that could be saved if blood testing was more efficient. This study presents a qualitative method to enable doctors and researchers to detect more than one virus simultaneously. This was performed using quartz nanoparticles. Using polymer thin films of polydimethylsiloxane (PDMS), each chip emits a different frequency for each specific type of virus on the chip. The multiplicity of these chips allows for the detection of a number of viruses with the same number of nanoscale chips simultaneously. Blood flow around quartz nanoparticles was modelled. In this model, several conventional Quartz Crystal Microbalance (QCM) with nanostructures (Nano-QCM) particles are inserted into the three main types of blood vessels. The results showed that the best location for the Nano-QCM is the large artery and that it is possible to test for a number of viruses in all types of blood vessels.

中文翻译:

定性理论模型,研究使用纳米石英晶体微量天平检测血液中多种病毒的可能性

研究人员和医生都关注测试血液中病毒存在的方法,因为它们确定了检测病毒的速度。通常,由于病毒对人体的严重影响,病毒检测是一个主要的科学问题。目前,在一次测试中只能检测到一种病毒。如果血液检测效率更高,这可能会使医疗机构花费更多的时间和金钱,从而节省更多时间和金钱。这项研究提出了一种定性方法,使医生和研究人员可以同时检测多种病毒。这是使用石英纳米颗粒进行的。使用聚二甲基硅氧烷(PDMS)的聚合物薄膜,每个芯片针对芯片上每种特定类型的病毒发出不同的频率。这些芯片的多样性允许同时使用相同数量的纳米级芯片检测多种病毒。对石英纳米颗粒周围的血流进行了建模。在该模型中,将几种具有纳米结构(Nano-QCM)颗粒的常规石英晶体微天平(QCM)插入三种主要类型的血管中。结果表明,Nano-QCM的最佳位置是大动脉,并且可以测试所有类型血管中的多种病毒。
更新日期:2020-07-20
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