Wet (neovascular) age‐related macular degeneration (AMD) is the leading cause of blindness in the United States. The mainstay treatment requires monthly intravitreal injection of anti‐vascular endothelial growth factor (anti‐VEGF) drugs, associated with multiple visits, high cost, and the risk of procedural injury and infection. Anti‐VEGF drugs inhibit the formation of neovasculature but do not directly attack it. Radiotherapy can destroy neovasculature and potentially also inhibit wet‐AMD associated inflammation and fibrosis not addressed by VEGF inhibitors. However, the current collimation‐based radiotherapy device uses fixed 4 mm beams, which are prone to overtreat or undertreat the choroidal neovascularization (CNV) lesions because of their various sizes and shapes. This simulation study evaluates personalized conformal treatment with focused kV radiation using cutting‐edge polycapillary x‐ray optics.

中文翻译：

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聚焦kV X射线放射治疗湿性年龄相关性黄斑变性的剂量学模型。

湿性（血管性）年龄相关性黄斑变性（AMD）是美国失明的主要原因。主体疗法需要每月玻璃体内注射抗血管内皮生长因子（anti-VEGF）药物，这与多次就诊，高成本以及程序性损伤和感染的风险相关。抗VEGF药物可抑制新血管系统的形成，但不能直接攻击它。放射疗法可以破坏新血管系统，并可能还抑制与湿AMD相关的炎症和纤维化，而VEGF抑制剂无法解决。但是，当前基于准直的放射治疗设备使用固定的4 mm光束，由于脉络膜新血管形成（CNV）病变的大小和形状各异，它们容易过度处理或不足。