M. carbonacea species produce the everninomicin antibiotics, elaborate oligosaccharides with potent antibacterial activity. Herein, we demonstrate a genetic system for genome editing of everninomicin producers, including a new microporous intergeneric conjugation system for conjugal transfer, and analyze a host of methyltransferases spanning the octasaccharide scaffold. In the process, several new everninomicin analogues were generated.

中文翻译：

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Everninomicin D 抗生素和类似物途径中的甲基转移酶偶发事件。

M. carbonacea物种产生everninomicin 抗生素，精心制作具有强效抗菌活性的寡糖。在此，我们展示了用于对依维尼诺霉素生产者进行基因组编辑的遗传系统，包括用于接合转移的新微孔属间接合系统，并分析了跨越八糖支架的大量甲基转移酶。在此过程中，产生了几种新的依维尼诺霉素类似物。