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Synergistic Anticancer Therapy by Ovalbumin Encapsulation-Enabled Tandem Reactive Oxygen Species Generation.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-07-19 , DOI: 10.1002/anie.202006649 Shuai Jiang 1, 2 , Ming Xiao 1, 3 , Wen Sun 1, 3 , Daniel Crespy 4 , Volker Mailänder 2, 5 , Xiaojun Peng 1 , Jiangli Fan 1, 3 , Katharina Landfester 2
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-07-19 , DOI: 10.1002/anie.202006649 Shuai Jiang 1, 2 , Ming Xiao 1, 3 , Wen Sun 1, 3 , Daniel Crespy 4 , Volker Mailänder 2, 5 , Xiaojun Peng 1 , Jiangli Fan 1, 3 , Katharina Landfester 2
Affiliation
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The anticancer efficacy of photodynamic therapy (PDT) is limited due to the hypoxic features of solid tumors. We report synergistic PDT/chemotherapy with integrated tandem Fenton reactions mediated by ovalbumin encapsulation for improved in vivo anticancer therapy via an enhanced reactive oxygen species (ROS) generation mechanism. O2.− produced by the PDT is converted to H2O2 by superoxide dismutase, followed by the transformation of H2O2 to the highly toxic .OH via Fenton reactions by Fe2+ originating from the dissolution of co‐loaded Fe3O4 nanoparticles. The PDT process further facilitates the endosomal/lysosomal escape of the active agents and enhances their intracellular delivery to the nucleus—even for drug‐resistant cells. Cisplatin generates O2.− in the presence of nicotinamide adenine dinucleotide phosphate oxidase and thereby improves the treatment efficiency by serving as an additional O2.− source for production of .OH radicals. Improved anticancer efficiency is achieved under both hypoxic and normoxic conditions.
中文翻译：
通过卵清蛋白封装串联活性氧产生的协同抗癌疗法。
由于实体瘤的缺氧特征，光动力疗法（PDT）的抗癌功效受到限制。我们报告了协同PDT/化疗与卵清蛋白封装介导的集成串联芬顿反应，通过增强的活性氧（ROS）生成机制改善体内抗癌治疗。PDT产生的O 2 .−被超氧化物歧化酶转化为H 2 O 2 ，随后H 2 O 2转化为剧毒物质。OH 通过 Fe 2+的 Fenton 反应产生，源自共负载的 Fe 3 O 4纳米粒子的溶解。PDT 过程进一步促进活性药物的内体/溶酶体逃逸，并增强它们向细胞核的细胞内递送——即使对于耐药细胞也是如此。顺铂在烟酰胺腺嘌呤二核苷酸磷酸氧化酶存在下产生O 2 .− ，从而通过充当产生的额外O 2 .−源来提高治疗效率。OH自由基。在缺氧和常氧条件下均可提高抗癌效率。
更新日期：2020-07-19
中文翻译：
通过卵清蛋白封装串联活性氧产生的协同抗癌疗法。
由于实体瘤的缺氧特征，光动力疗法（PDT）的抗癌功效受到限制。我们报告了协同PDT/化疗与卵清蛋白封装介导的集成串联芬顿反应，通过增强的活性氧（ROS）生成机制改善体内抗癌治疗。PDT产生的O 2 .−被超氧化物歧化酶转化为H 2 O 2 ，随后H 2 O 2转化为剧毒物质。OH 通过 Fe 2+的 Fenton 反应产生，源自共负载的 Fe 3 O 4纳米粒子的溶解。PDT 过程进一步促进活性药物的内体/溶酶体逃逸，并增强它们向细胞核的细胞内递送——即使对于耐药细胞也是如此。顺铂在烟酰胺腺嘌呤二核苷酸磷酸氧化酶存在下产生O 2 .− ，从而通过充当产生的额外O 2 .−源来提高治疗效率。OH自由基。在缺氧和常氧条件下均可提高抗癌效率。
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