The whole genome of Alteromonas pelagimontana 5.12^T, a psychrotolerant deep-sea bacterium isolated from the sediment sample of eastern Southwest Indian Ridge, was sequenced and analysed for understanding its metabolic capacities and biosynthesis potential of natural products. The circular genome contained 4.3 Mb with a GC content of 42.6 mol%. Genomic data mining revealed a gene cluster for heavy metal resistance (czcABC, acrB, arsR1, copA, nikA, mntH, mntP), exopolysaccharides (EPS; epsCDEFHLM) and polyhydroxyalkanoates (PHA; phbC) production, as well as genes involved in complex polysaccharide degradation. Genes that could allow strain 5.12^T to cope with acid stress (ibaG) and heat shock (ibpA, hslR) were observed along with ten chaperone-encoding genes which could possibly play vital role in adaptability of this strain to the hydrothermally influenced environment. Gene clusters for secondary metabolite production such as bacteriocin and arylpolyene were also predicted. Thus, genome sequencing and data mining provided insights into the molecular mechanisms involved in the adaptation to hydrothermally influenced deep-sea environment that could promote further experimental exploration.

Alteromonas pelagimontana 5.12 ^T的全基因组是从印度西南海脊东部沉积物样本中分离出来的一种耐冷深海细菌，经过测序和分析，以了解其代谢能力和天然产物的生物合成潜力。环状基因组包含 4.3 Mb，GC 含量为 42.6 mol%。基因组数据挖掘揭示了重金属抗性基因簇（czcABC、acrB、arsR1、copA、nikA、mntH、mntP）、胞外多糖（EPS；epsCDEFHLM）和聚羟基链烷酸酯（PHA；phbC）生产，以及参与复杂多糖的基因降解。允许应变 5.12 ^T应对酸胁迫的基因（ibaG ) 和热休克 ( ibpA, hslR ) 与十个分子伴侣编码基因一起被观察到，这些基因可能在该菌株对热液影响环境的适应性中起重要作用。还预测了用于次级代谢产物产生的基因簇，例如细菌素和芳基多烯。因此，基因组测序和数据挖掘提供了对适应受热液影响的深海环境所涉及的分子机制的见解，可以促进进一步的实验探索。