In Argentina, a multi-institutional project has been established to assess the feasibility of applying BNCT ex-situ to the treatment of patients with multiple metastases in both lungs. Within this context, this work aims at applying the neutron autoradiography technique to study boron microdistribution in the lung. A comprehensive analysis of the different aspects for the generation of autoradiographic images of both normal and metastatic BDIX rat lungs was achieved. Histology, boron uniformity, optimal tissue thickness and water content in tissue were explored for the two types of samples. A qualitative and a quantitative analysis were performed. No heterogeneities in uptake were observed in normal lung. Conversely, samples with metastasis showed preferential boron uptake in the tumour areas with respect to surrounding tissue. Surrounding tissue would present a slightly higher uptake of boron than the normal lung. Quantitative results of boron concentration values and ratios determined by neutron autoradiography were obtained. In order to contribute to BNCT dosimetry, further analysis increasing the number of samples is warranted.

在阿根廷，已经建立了一个多机构项目来评估 BNCT异地应用的可行性用于治疗双肺多发转移患者。在此背景下，这项工作旨在应用中子放射自显影技术研究硼在肺中的微分布。对生成正常和转移性 BDIX 大鼠肺的放射自显影图像的不同方面进行了综合分析。研究了两种类型样品的组织学、硼均匀性、最佳组织厚度和组织中的含水量。进行了定性和定量分析。在正常肺中未观察到摄取的异质性。相反，有转移的样本显示出相对于周围组织在肿瘤区域中优先吸收硼。与正常肺相比，周围组织对硼的吸收略高。获得了通过中子放射自显影确定的硼浓度值和比率的定量结果。为了有助于 BNCT 剂量测定，需要进一步分析增加样本数量。