Graphitic carbon nitrides supported cuprous oxide architecture is reported as an efficient electrode material for supercapacitors, especially due to its high charge-transfer conductivity of the electrochemical devices. Herein, we present an electrochemical sensor to specifically detect 8-hydroxy-2′-deoxyguanosine (8-HDG) oxidative stress biomarker using graphitic carbon nitrides that decorate a cuprous oxide cubes modified electrode. The fabricated electrochemical sensor was characterized and proved by electrochemical methods, EDX, FESEM, and amperometry (i–t). In the presence of 8-hydroxy-2′-deoxyguanosine (8-HDG), the effective interaction between graphitic carbon nitrides and 8-HDG favors the accumulation on the Cu2O/g-C3N4/GCE, which increases the electrocatalytic property and amperometric response. The proposed electrochemical sensor exhibits a wide linear range for 8-HDG in 0.1 M phosphate buffer (pH 7.0) from 25 nM to 0.91 mM, and the limit of detection (LOD) is 4.5 nM. The stability of the Cu2O/g-C3N4/GCE is improved when stored at 4 °C. The repeatability and reproducibility of this electrochemical sensor is good and the sensor retains its current response for 8-HDG detection also after long time storage. The modified sensor proved high selectivity and sensitivity for 8-HDG, which made it possible to determine 8-HDG in biological samples. Furthermore, the Cu2O/g-C3N4/GCE offered a favorable electron transfer between the Cu2O/g-C3N4 and the electrode interface compared to Cu2O/GCE, g-C3N4/GCE, and unmodified GCE. Graphical abstract Electrochemical detection of oxidative stress marker based on Cu2O@g-C3N4 materials modified electrode. Electrochemical detection of oxidative stress marker based on Cu2O@g-C3N4 materials modified electrode.

中文翻译：

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一种由氧化亚铜负载在石墨氮化碳纳米片上的纳米复合材料，用于 8-羟基-2'-脱氧鸟苷的非酶促电化学传感

据报道，石墨氮化碳支撑的氧化亚铜结构是一种有效的超级电容器电极材料，特别是由于其电化学装置的高电荷转移导电性。在此，我们提出了一种电化学传感器，使用装饰氧化亚铜立方体修饰电极的石墨氮化碳来特异性检测 8-羟基-2'-脱氧鸟苷 (8-HDG) 氧化应激生物标志物。通过电化学方法、EDX、FESEM 和电流分析法 (i-t) 对制造的电化学传感器进行表征和证明。在 8-羟基-2'-脱氧鸟苷 (8-HDG) 存在下，石墨碳氮化物和 8-HDG 之间的有效相互作用有利于在 Cu2O/g-C3N4/GCE 上的积累，从而提高电催化性能和电流响应. 所提出的电化学传感器对 8-HDG 在 0.1 M 磷酸盐缓冲液 (pH 7.0) 中的线性范围为 25 nM 至 0.91 mM，检测限 (LOD) 为 4.5 nM。Cu2O/g-C3N4/GCE 的稳定性在 4 °C 下储存时得到改善。这种电化学传感器的重复性和再现性良好，并且在长时间储存​​后，该传感器仍能保持其对 8-HDG 检测的电流响应。改进的传感器证明了对 8-HDG 的高选择性和灵敏度，这使得测定生物样品中的 8-HDG 成为可能。此外，与 Cu2O/GCE、g-C3N4/GCE 和未改性的 GCE 相比，Cu2O/g-C3N4/GCE 在 Cu2O/g-C3N4 和电极界面之间提供了有利的电子转移。基于Cu2O@g-C3N4材料修饰电极的氧化应激标志物电化学检测图