Many immune cells participate in the pathogenesis of ulcerative colitis (UC), and fatty acid metabolism (FAM) is reported to supporting their cell-specific functions and proliferation, but the underlying mechanism is unclear. This study aimed to investigate the relationship between FAM and inflammation in colon tissues and identify potential therapeutic targets for regulating immune response. A total of 870 different expression genes (DEGs), 304 immunity-related DEGs, and 11 FAM-related DEGs were obtained, gene ontology analysis results showed that immune DEGs were significantly enriched in neutrophil migration, positive regulation of T cell activation. Fifteen types of immune cells were identified in inflamed colon tissues. Five FAM-related DEGs (ACOX1, ACSL4, ELOVL5, FADS2, and SCD) were highly correlated with immunity-related DEGs, and ACSL4, ELOVL5, and FADS2 were significantly upregulated in immune cells, while SCD is downregulated. Five FAM-related DEGs were highly correlated with immune cells. The study promotes the understanding of the pathogenesis of FAM in UC immune cells

中文翻译：

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免疫细胞中的脂肪酸代谢：溃疡性结肠炎相关基因的生物信息学分析。

许多免疫细胞参与溃疡性结肠炎（UC）的发病机制，据报道脂肪酸代谢（FAM）支持其细胞特异性功能和增殖，但其潜在机制尚不清楚。这项研究旨在调查FAM与结肠组织炎症之间的关系，并确定调节免疫应答的潜在治疗靶标。总共获得870个不同的表达基因（DEG），304个免疫相关的DEG和11个FAM相关的DEG，基因本体分析结果表明免疫DEG在嗜中性粒细胞迁移，T细胞活化的正调控方面显着丰富。在发炎的结肠组织中鉴定出15种免疫细胞。五个与FAM相关的DEG（ACOX1，ACSL4，ELOVL5，FADS2和SCD）与免疫相关的DEGs高度相关，并且ACSL4，ELOVL5和FADS2在免疫细胞中显着上调，而SCD被下调。五个与FAM相关的DEG与免疫细胞高度相关。这项研究促进了对UC免疫细胞中FAM发病机理的了解