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Shed it, and help-LAG3 cleavage drives conventional CD4+ T cells to overcome resistance to PD-1 immunotherapy.
Science Immunology ( IF 17.6 ) Pub Date : 2020-07-17 , DOI: 10.1126/sciimmunol.abc8644
Lea Seidel 1, 2, 3, 4 , Bertram Bengsch 1, 2
Affiliation  

LAG3 cleavage from conventional CD4+ T cells, but not CD8+ T cells, is required for effective PD-1 blockade.



中文翻译:

摆脱它,help-LAG3 切割驱动传统的 CD4+ T 细胞克服对 PD-1 免疫疗法的耐药性。

有效的 PD-1 阻断需要从常规 CD4 + T 细胞而非 CD8 + T 细胞切割 LAG3 。

更新日期:2020-07-18
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