Temperature and relative humidity are major factors determining virus inactivation in the environment. This article reviews inactivation data regarding coronaviruses on surfaces and in liquids from published studies and develops secondary models to predict coronaviruses inactivation as a function of temperature and relative humidity. A total of 102 D values (i.e., the time to obtain a log₁₀ reduction of virus infectivity), including values for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), were collected from 26 published studies. The values obtained from the different coronaviruses and studies were found to be generally consistent. Five different models were fitted to the global data set of D values. The most appropriate model considered temperature and relative humidity. A spreadsheet predicting the inactivation of coronaviruses and the associated uncertainty is presented and can be used to predict virus inactivation for untested temperatures, time points, or any coronavirus strains belonging to Alphacoronavirus and Betacoronavirus genera.

中文翻译：

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模拟冠状病毒科病毒对悬浮液或表面温度和相对湿度的灭活反应。


温度和相对湿度是决定环境中病毒灭活的主要因素。本文回顾了已发表的研究中关于表面和液体中冠状病毒的灭活数据，并开发了二级模型来预测冠状病毒灭活随温度和相对湿度的变化。从 26 项已发表的研究中收集了总共 102 个D值（即病毒感染性减少 log ₁₀的时间），包括严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的值。发现从不同冠状病毒和研究中获得的值总体上是一致的。将五个不同的模型拟合到D值的全局数据集。最合适的模型考虑了温度和相对湿度。提出了一个预测冠状病毒失活和相关不确定性的电子表格，可用于预测未经测试的温度、时间点或属于Alpha 冠状病毒和Beta 冠状病毒属的任何冠状病毒株的病毒失活。