Due to limitations of treatment and the stubbornness of infiltrative tumor cells, the outcome of conventional antitumor treatment is often compromised by a variety of factors, including severe side effects, unexpected recurrence, and massive tissue loss during the treatment. Hydrogel‐based therapy is becoming a promising option of cancer treatment, because of its controllability, biocompatibility, high drug loading, prolonged drug release, and specific stimuli‐sensitivity. Hydrogel‐based therapy has good malleability and can reach some areas that cannot be easily touched by surgeons. Furthermore, hydrogel can be used not only as a carrier for tumor treatment agents, but also as a scaffold for tissue repair. In this review, we presented the latest researches in hydrogel applications of localized tumor therapy and highlighted the recent progress of hydrogel‐based therapy in preventing postoperative tumor recurrence and improving tissue repair, thus proposing a new trend of hydrogel‐based technology in localized tumor therapy. And this review aims to provide a novel reference and inspire thoughts for a more accurate and individualized cancer treatment.

中文翻译：

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水凝胶治疗平台在局部肿瘤治疗中的进展与趋势：综述

由于治疗的局限性和浸润性肿瘤细胞的顽固性，常规抗肿瘤治疗的结果往往受到多种因素的影响，包括严重的副作用、意外复发和治疗过程中的大量组织损失。基于水凝胶的治疗因其可控性、生物相容性、高载药量、延长药物释放和特异性刺激敏感性而成为一种有前景的癌症治疗选择。基于水凝胶的疗法具有良好的延展性，可以到达一些外科医生不易触及的区域。此外，水凝胶不仅可以用作肿瘤治​​疗剂的载体，还可以用作组织修复的支架。在这次审查中，我们介绍了水凝胶在局部肿瘤治疗中应用的最新研究，重点介绍了基于水凝胶的治疗在预防术后肿瘤复发和改善组织修复方面的最新进展，从而提出了基于水凝胶技术在局部肿瘤治疗中的新趋势。这篇综述旨在为更准确和个性化的癌症治疗提供新的参考和启发思路。