Review on druggable targets of key age-associated properties regulated by therapeutic agents.,Chemical Biology & Drug Design

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Review on druggable targets of key age-associated properties regulated by therapeutic agents.
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2020-07-17 , DOI: 10.1111/cbdd.13759
Ambili Unni P ₁ , Sajitha Lulu Sudhakaran ₁ , Girinath G Pillai _{1,

2}

Affiliation

Aging is a biological process which accounts for the deterioration of effective physiological functions. The malfunctioning of vital organ systems leads to the onset of neurodegenerative, cardiovascular, and immunomodulatory diseases in the elder population. Age‐dependent mitochondrial dysfunctions trigger the production of reactive oxygen species, which serve as a major contributing factor for the onset of age‐associated diseases. The increasing burden of age‐related pathologies explicates the relevance of identifying novel therapeutic agents with enhanced potency and bioavailability. Key information on the biological mechanisms of significant age‐related diseases aids in understanding relevant druggable targets essential for the initiation and progression of the disease. This review provides detailed insights into the druggable targets of key anti‐aging properties of therapeutic agents such as anti‐oxidant, immunomodulation, cardioprotection, anti‐melanogenic, and anti‐elastase properties. This information aids in the development of novel therapeutic agents/ supplements with enhanced efficacy.

中文翻译：

综述了由治疗药物调节的与年龄相关的关键特性的药物靶向。

衰老是导致有效生理功能下降的生物学过程。重要器官系统的功能障碍导致老年人中神经退行性疾病，心血管疾病和免疫调节疾病的发作。取决于年龄的线粒体功能障碍会触发活性氧的产生，这是导致与年龄有关的疾病的主要因素。与年龄有关的病理学日益增加的负担使鉴定具有增强的效力和生物利用度的新型治疗剂的相关性变得复杂。有关与年龄相关的重大疾病的生物学机制的关键信息有助于理解该疾病的发生和发展必不可少的相关药物目标。这篇综述对治疗剂的关键抗衰老特性（例如抗氧化剂，免疫调节，心脏保护作用，抗黑素生成和抗弹性蛋白酶特性）的可药物化靶点提供了详细的见解。该信息有助于开发具有增强功效的新型治疗剂/补充剂。

更新日期：2020-08-25

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