Coronavirus disease 2019 or COVID‐19 is an emerging viral disease caused by a member of the betacoronavirus family, SARS‐CoV‐2. Since its' emergence in December 2019, it has rapidly caused close to half a million fatalities globally. Data regarding the impact of COVID‐19 on pregnancy are limited. Here, we review pathological findings in placentas from women who tested positive for SARS‐CoV‐2 as well as information on pregnancy outcomes associated with related and highly pathogenic coronaviruses (ie, severe acute respiratory syndrome (SARS‐COV) and the Middle East respiratory syndrome, MERS). We present immune‐inflammatory correlates of COVID‐19 in pregnancy and review the role of the Renin Angiotensin System in the pathogenesis of COVID‐19 in pregnancy. Greater understanding of the pathogenesis of SARS‐CoV‐2 in the placenta will yield important insight into potential therapeutic interventions for pregnant women with COVID‐19.

中文翻译：

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SARS-CoV2 和怀孕：看不见的敌人？


2019 冠状病毒病或 COVID-19 是一种新出现的病毒性疾病，由 β 冠状病毒家族成员 SARS-CoV-2 引起。自 2019 年 12 月出现以来，它已迅速在全球造成近 50 万人死亡。有关 COVID-19 对妊娠影响的数据有限。在这里，我们回顾了 SARS-CoV-2 检测呈阳性的女性胎盘的病理结果，以及与相关和高致病性冠状病毒（即严重急性呼吸综合征（SARS-COV）和中东呼吸道疾病）相关的妊娠结局信息。综合症、MERS）。我们介绍了妊娠期 COVID-19 的免疫炎症相关性，并回顾了肾素血管紧张素系统在妊娠期 COVID-19 发病机制中的作用。更好地了解 SARS-CoV-2 在胎盘中的发病机制将为了解针对感染 COVID-19 的孕妇的潜在治疗干预措施提供重要见解。