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Simple Repeats as Building Blocks for Genetic Computers.
Trends in Genetics ( IF 13.6 ) Pub Date : 2020-07-18 , DOI: 10.1016/j.tig.2020.06.012
Alan Herbert 1
Affiliation  

Processing of RNA involves heterogeneous nuclear ribonucleoproteins. The simple sequence repeats (SSRs) they bind can also adopt alternative DNA structures, like Z DNA, triplexes, G quadruplexes, and I motifs. Those SSRs capable of switching conformation under physiological conditions (called flipons) are genetic elements that can encode alternative RNA processing by their effects on RNA processivity, most likely as DNA:RNA hybrids. Flipons are elements of a binary, instructive genetic code directing how genomic sequences are compiled into transcripts. The combinatorial nature of this code provides a rich set of options for creating genetic computers able to reproduce themselves and use a heritable and evolvable code to optimize survival. The underlying computational logic potentiates a diverse set of genetic programs that modify cis-mediated heritability and disease risk.



中文翻译:

简单重复作为遗传计算机的基础。

RNA的加工涉及异质核核糖核蛋白。它们结合的简单序列重复序列(SSR)也可以采用其他DNA结构,例如Z DNA,三链体,G四链体和I基序。那些能够在生理条件下转换构象的SSR(称为Flipon)是遗传元件,可通过其对RNA合成能力的影响来编码其他RNA加工,最有可能是DNA:RNA杂种。Flipons是指导性的二进制遗传密码的元素,该遗传密码指示如何将基因组序列编译成转录本。该代码的组合性质为创建能够自我复制并使用可遗传和可进化的代码来优化生存的遗传计算机提供了丰富的选择。潜在的计算逻辑增强了多种遗传程序,这些遗传程序可以修改顺式介导的遗传力和疾病风险。

更新日期:2020-09-14
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