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Genetic structure of Tunisian sheep breeds as inferred from genome-wide SNP markers
Small Ruminant Research ( IF 1.6 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.smallrumres.2020.106192
S. Bedhiaf-Romdhani , I. Baazaoui , E. Ciani , S. Mastrangelo , M. Ben Sassi

Abstract Assessing the status of genetic variability of native sheep breeds could provide important clues for research and policy makers to devise better strategies for the conservation and management of genetic resources. In this study, a genetic investigation of Tunisian sheep breeds using a genome-wide scan of approximately 50,000 SNPs was performed. To reconstruct genetic structure and relationships among four sheep breeds, 40 samples belonging to fat-tailed Barbarine, Queue Fine de l’Ouest, Noire de Thibar and D’Man breeds were genotyped using Illumina Ovine SNP50 BeadChip. Tunisian breeds averaged 96 % polymorphic loci with an expected heterozygosity (He = 0.36). Genetic analysis of relationship between breeds using Bayesian clustering, MDS and Neighbor-Network analysis, and estimation of FST genetic structure, highlighted the genetic differentiation of Noire de Thibar breed from the other local breeds, reflecting the effect of past events of introgression of European gene pool. The Queue Fine de l’Ouest breed showed a genetic heterogeneity and was close to Barbarine and D'Man breeds, as evidenced by MDS and the lowest level of differentiation with Barbarine breed (FST = 1.8 %). The D'Man breed shared a considerable gene flow with the thin-tailed Queue Fine de l'Ouest breed. Possible factors explaining the genetic patterns observed, such as considerable gene flow probably due to anthropogenic activities in the light of population management and conservation programs.

中文翻译:

从全基因组 SNP 标记推断的突尼斯绵羊品种的遗传结构

摘要 评估本地绵羊品种的遗传变异状况可以为研究和决策者设计更好的遗传资源保护和管理策略提供重要线索。在这项研究中,使用大约 50,000 个 SNP 的全基因组扫描对突尼斯绵羊品种进行了遗传调查。为了重建四个绵羊品种之间的遗传结构和关系,使用 Illumina Ovine SNP50 BeadChip 对属于肥尾 Barbarine、Queue Fine de l'Ouest、Noire de Thibar 和 D'Man 品种的 40 个样本进行基因分型。突尼斯品种平均 96% 的多态性位点具有预期的杂合性 (He = 0.36)。使用贝叶斯聚类、MDS 和 Neighbor-Network 分析对品种之间的关系进行遗传分析,以及 FST 遗传结构的估计,强调了 Noire de Thibar 品种与其他当地品种的遗传差异,反映了过去欧洲基因库基因渗入事件的影响。Queue Fine de l'Ouest 品种表现出遗传异质性,接近 Barbarine 和 D'Man 品种,MDS 证明了这一点,并且 Barbarine 品种的分化水平最低(FST = 1.8 %)。D'Man 品种与细尾 Queue Fine de l'Ouest 品种共享相当多的基因流。解释观察到的遗传模式的可能因素,例如根据人口管理和保护计划可能由于人为活动引起的大量基因流动。Queue Fine de l'Ouest 品种表现出遗传异质性,接近 Barbarine 和 D'Man 品种,MDS 证明了这一点,并且 Barbarine 品种的分化水平最低(FST = 1.8 %)。D'Man 品种与细尾 Queue Fine de l'Ouest 品种共享相当多的基因流。解释观察到的遗传模式的可能因素,例如根据人口管理和保护计划可能由于人为活动引起的大量基因流动。Queue Fine de l'Ouest 品种表现出遗传异质性,接近 Barbarine 和 D'Man 品种,MDS 证明了这一点,并且 Barbarine 品种的分化水平最低(FST = 1.8 %)。D'Man 品种与细尾 Queue Fine de l'Ouest 品种共享相当多的基因流。解释观察到的遗传模式的可能因素,例如根据人口管理和保护计划可能由于人为活动引起的大量基因流动。
更新日期:2020-10-01
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