The design and development of new routes for the production of sustainable bulk-chemicals requires focus on feedstock, conversion technology and downstream product recovery. This brief article discusses some of the constraints with using fermentation and suggests the removal of some constraints by using microbial biocatalysis or enzyme biocatalysis, which give a number of benefits in the context of the requirements for bulk-chemical production. Some potential process concepts are described, for products in the suitable low-price range. These examples (biodiesel, furfurals and amines) are used to illustrate the power of biocatalysis. Suggestions for future research efforts beyond molecular biology, involving process-based concepts, are also discussed.

中文翻译：

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使用生物技术实现大宗化学品的可持续生产

可持续大宗化学品生产新路线的设计和开发需要关注原料、转化技术和下游产品回收。这篇简短的文章讨论了使用发酵的一些限制，并建议通过使用微生物生物催化或酶生物催化来消除一些限制，这在大宗化学品生产要求的背景下提供了许多好处。描述了一些潜在的工艺概念，适用于合适的低价范围内的产品。这些例子（生物柴油、糠醛和胺）用于说明生物催化的力量。还讨论了对分子生物学以外的未来研究工作的建议，包括基于过程的概念。