Both the GH/IGF-1 axis and the gut microbiota independently play an important role in host growth, metabolism, and intestinal homeostasis. Inversely, abnormalities in GH action and microbial dysbiosis (or a lack of diversity) in the gut have been implicated in restricted growth, metabolic disorders (such as chronic undernutrition, anorexia nervosa, obesity, and diabetes), and intestinal dysfunction (such as pediatric Crohn's disease, colonic polyps, and colon cancer). Over the last decade, studies have demonstrated that the microbial impact on growth may be mediated through the GH/IGF-1 axis, pointing toward a potential relationship between GH and the gut microbiota. This review covers current research on the GH/IGF-1 axis and the gut microbiome and its influence on overall host growth, metabolism, and intestinal health, proposing a bidirectional relationship between GH and the gut microbiome.

GH/IGF-1 轴和肠道微生物群均在宿主生长、代谢和肠道稳态​​中独立发挥重要作用。相反，肠道中 GH 作用的异常和微生物生态失调（或缺乏多样性）与生长受限、代谢紊乱（如慢性营养不良、神经性厌食、肥胖和糖尿病）和肠道功能障碍（如儿科疾病）有关。克罗恩病、结肠息肉和结肠癌）。在过去十年中，研究表明微生物对生长的影响可能是通过 GH/IGF-1 轴介导的，这表明 GH 与肠道微生物群之间存在潜在关系。这篇综述涵盖了当前关于 GH/IGF-1 轴和肠道微生物组的研究及其对整体宿主生长、代谢和肠道健康的影响，