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Evaluation of a flash glucose monitoring system in dogs with diabetic ketoacidosis.
Domestic Animal Endocrinology ( IF 1.9 ) Pub Date : 2020-07-18 , DOI: 10.1016/j.domaniend.2020.106525
D D Silva 1 , G R M Cecci 1 , G Biz 2 , F N Chiaro 1 , M S Zanutto 1
Affiliation  

The flash glucose monitoring system (FGMS) Freestyle Libre provides estimates of blood glucose by constantly measuring the glucose concentration of the interstitial fluid through a sensor inserted in the subcutaneous space. The aim of this study was to evaluate the applicability and accuracy of the FGMS in dogs with diabetic ketoacidosis (DKA). Seven dogs with DKA examined at the Veterinary Hospital of the State University of Londrina were included in this study. The sensor was placed on the dorsal cervical region, shortly after the diagnosis of DKA was confirmed and maintained for 5 d. The measurement of blood glucose was performed simultaneously with the veterinary portable blood glucose meter (PBGM) AlphaTRAK 2 every 2 to 4 h and with the hexokinase method every 12 h. The PBGM's precision was evaluated following the ISO15197:2013 criteria. Blood glucose estimates were strongly associated (r = 0.89; P < 0.0001), and the mean absolute relative difference in relation to the PBGM was 25.2% (−70.4% to 101.9%). The evaluation of these data using the consensus error grid analysis showed that 95.4% and 94.8% of the samples were in Zones A and B (clinically acceptable) using the PBGM and the hexokinase method as a reference, respectively. The ISO15197:2013 criteria were not met. There was no difference in the accuracy of the device among days (P = 0.74); however, there was a difference between the hydration status (P = 0.019) and blood glucose ranges (hypoglycemic, euglycemic, and hyperglycemic; P < 0.0001), in which it was less precise in measuring the blood glucose range in hypoglycemic dogs. Therefore, it can be concluded that in spite of the fact that the device did not meet the ISO 15197:2013 criteria, the FGMS evaluated presents good clinical precision and can be a valuable tool in treating dogs with diabetic DKA.



中文翻译:

糖尿病酮症酸中毒犬快速血糖监测系统的评估。

快速血糖监测系统 (FGMS) Freestyle Libre 通过插入皮下空间的传感器不断测量间质液的葡萄糖浓度,从而提供血糖估计值。本研究的目的是评估 FGMS 在糖尿病酮症酸中毒 (DKA) 犬中的适用性和准确性。本研究包括在隆德里纳州立大学兽医医院检查的七只患有 DKA 的狗。在确认 DKA 诊断后不久,将传感器放置在颈背区域并保持 5 天。使用兽医便携式血糖仪 (PBGM) AlphaTRAK 2 每 2 至 4 小时测量一次血糖,并每 12 小时使用己糖激酶法测量血糖。根据 ISO15197:2013 标准评估 PBGM 的精度。P < 0.0001),与 PBGM 相关的平均绝对相对差异为 25.2%(-70.4% 至 101.9%)。使用共识误差网格分析对这些数据的评估表明,分别使用 PBGM 和己糖激酶方法作为参考,95.4% 和 94.8% 的样本位于 A 区和 B 区(临床可接受)。不符合 ISO15197:2013 标准。设备的准确度在几天内没有差异(P = 0.74);然而,水合状态(P = 0.019)和血糖范围(低血糖、正常血糖和高血糖;P< 0.0001),其中在测量低血糖犬的血糖范围时不太精确。因此,可以得出结论,尽管该设备不符合 ISO 15197:2013 标准,但评估的 FGMS 表现出良好的临床精度,可以成为治疗患有糖尿病 DKA 的狗的宝贵工具。

更新日期:2020-07-18
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