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Multiphase flow in microfluidics: From droplets and bubbles to the encapsulated structures.
Advances in Colloid and Interface Science ( IF 15.9 ) Pub Date : 2020-07-18 , DOI: 10.1016/j.cis.2020.102208
Amirmohammad Sattari 1 , Pedram Hanafizadeh 2 , Mina Hoorfar 3
Affiliation  

Microfluidic technologies have a unique ability to control more precisely and effectively on two-phase flow systems in comparison with macro systems. Controlling the size of the droplets and bubbles has led to an ever-increasing expansion of this technology in two-phase systems. Liquid-liquid and gas-liquid two-phase flows because of their numerous applications in different branches such as reactions, synthesis, emulsions, cosmetic, food, drug delivery, etc. have been the most critical two-phase flows in microfluidic systems. This review highlights recent progress in two-phase flows in microfluidic devices. The fundamentals of two-phase flows, including some essential dimensionless numbers, governing equations, and some most well-known numerical methods are firstly introduced, followed by a review of standard methods for producing segmented flows such as emulsions in microfluidic systems. Then various encapsulated structures, a common two-phase flow structure in microfluidic devices, and different methods of their production are reviewed. Finally, applications of two-phase microfluidic flows in drug-delivery, biotechnology, mixing, and microreactors are briefly discussed.



中文翻译:

微流体中的多相流:从液滴和气泡到封装结构。

与宏系统相比,微流体技术具有独特的能力,可以对两相流系统进行更精确,更有效的控制。控制液滴和气泡的大小已导致该技术在两相系统中的不断扩展。液-液和气-液两相流由于它们在不同分支中的大量应用,例如反应,合成,乳液,化妆品,食品,药物输送等,已成为微流体系统中最关键的两相流。这篇综述着重介绍了微流体装置两相流的最新进展。首先介绍了两相流的基本原理,包括一些基本的无量纲数,控制方程和一些最著名的数值方法,随后回顾了在微流体系统中生产分段流(例如乳液)的标准方法。然后审查了各种封装的结构,微流控设备中常见的两相流结构,以及不同的生产方法。最后,简要讨论了两相微流在药物输送,生物技术,混合和微反应器中的应用。

更新日期:2020-07-25
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