Abstract

The rheological characteristics of polymer mixtures used for making multilayer polyelectrolyte covers on carbonate cores in drug delivery systems were studied. The cover structure is primarily determined by the first polymer layer, its excess charge, concentration, and ionic surrounding. The correctness of the interpretation of the viscometric data is confirmed by scanning electron microscopic examination of carbonate cores with polymer covers formed under different conditions. The molecular mass of the polymers influences the release profiles of a therapeutic protein encapsulated in delivery systems into liquids simulating gastrointestinal media.

中文翻译：

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形成碳酸钙核覆盖层的聚合物。它们的流变特性对口服给药系统结构和功能的影响

摘要

研究了在药物递送系统中用于在碳酸酯核上制备多层聚电解质覆盖物的聚合物混合物的流变特性。覆盖结构主要由第一聚合物层，其过量电荷，浓度和离子周围环境决定。粘度数据解释的正确性通过在不同条件下形成的带有聚合物覆盖层的碳酸盐岩心的扫描电子显微镜检查得到证实。聚合物的分子量影响封装在递送系统中的治疗性蛋白质向模拟胃肠道介质的液体中的释放曲线。