A new method for diagnosis of diabetes mellitus is proposed, which uses for measurement a lyophilized blood plasma sample prepared in the form of a pellet. The paper develops a methodology for fast spectroscopic measurements of such pellets with terahertz pulse time-domain holography. For that reason, blood plasma pellets were experimentally measured by terahertz time-domain spectroscopy system in transmission mode and its characteristics were obtained to be then used in numerical simulation of pulse terahertz hologram formation and extraction of its optical properties. Thus, a demonstration of the proof-of-concept was given for the techniques of pellet inspection, which contains information about the presence of glycated proteins, reflecting a diabetic pathology.

提出了一种诊断糖尿病的新方法，该方法用于测量以小球形式制备的冻干血浆样品。本文开发了一种利用太赫兹脉冲时域全息术快速光谱测量此类颗粒的方法。因此，通过太赫兹时域光谱系统以透射模式对血浆沉淀物进行了实验测量，获得了其特性，然后将其用于脉冲太赫兹全息图形成的数值模拟及其光学性质的提取。因此，对颗粒检查技术进行了概念验证，其中包含有关糖化蛋白存在的信息，反映了糖尿病的病理学。