The prevalence of chronic diseases is increasing in people living with HIV (PLHIV) in the post ART era. Sarcopenia is prevalent in the elderly and is associated with many chronic diseases. Our study aimed to evaluate the frequency of sarcopenia in PLHIV and its association with bone mineral density and fracture. A cross-sectional study was carried out at Santa Maria, South Brazil. It included PLHV age ≥ 50 years and registered to receive antiretroviral therapy. A structured questionnaire was applied, blood samples collected, muscle strength evaluated, body composition measured, and vertebral morphometry performed. Sarcopenia and presarcopenia were defined according to the European Working Group on Sarcopenia in Older People. Of the 101 patients recruited, 83 underwent DXA and muscle strength measurements. The prevalence of sarcopenia and presarcopenia in the individuals studied was 12% and 16.9%, respectively. 66.7% of sarcopenic individuals had morphometric vertebral fractures and there was a tendency towards a higher frequency of multiple vertebral fractures when compared with non-sarcopenic subjects (44.4% vs. 16.2%, p = 0.066). BMI and total hip BMD were significantly lower in sarcopenic than non-sarcopenic individuals (p ≥ 0.035 and 0.032 respectively). In multiple regression analysis, sarcopenia was associated with age and multiple vertebral fractures. Sarcopenia was present in 12% of this population of PLHIV age ≥ 50 years and was associated with lower hip BMD and a high prevalence of vertebral fractures.

在后ART时代，艾滋病毒感染者（PLHIV）的慢性病患病率正在增加。肌肉减少症在老年人中普遍存在，并与许多慢性疾病有关。我们的研究旨在评估PLHIV肌肉减少症的频率及其与骨矿物质密度和骨折的关系。在巴西南部的圣玛丽亚进行了横断面研究。它包括年龄≥50岁的PLHV，并注册接受抗逆转录病毒治疗。应用结构化问卷，收集血液样本，评估肌肉力量，测量身体成分，并进行椎体形态测量。肌肉减少症和肌肉减少症是根据欧洲老年人肌肉减少症工作组定义的。在招募的101位患者中，有83位接受了DXA和肌肉力量测量。在研究对象中，肌肉减少症和肌肉减少症的患病率分别为12％和16.9％。66.7％的肌肉减少症患者具有形态特征性椎体骨折，与非肌肉减少症患者相比，多发性椎骨骨折的发生率较高（44.4％对16.2％，p  = 0.066）。BMI和全髋BMD均sarcopenic显著低于非sarcopenic个体（p  ≥0.035 0.032分别）。在多元回归分析中，肌肉减少症与年龄和多发性脊椎骨折有关。肌肉减少症存在于年龄≥50岁的PLHIV人群中的12％，并与下髋骨BMD和椎骨骨折的高患病率有关。