Recently, methods have been introduced using polygenic scores (PGS) to estimate the effects of genetic nurture, the environmentally-mediated effects of parental genotypes on the phenotype of their child above and beyond the effects of the alleles which are transmitted to the child. We introduce a simplified model for estimating genetic nurture effects and show, through simulation and analytical derivation, that our method provides unbiased estimates and offers an increase in power to detect genetic nurture of up to 1/3 greater than that of previous methods. Subsequently, we apply this method to data from the Avon Longitudinal Study of Parents and Children to estimate the effects of maternal genetic nurture on childhood body mass index (BMI) trajectories. Through mixed modeling, we observe a statistically significant age-dependent effect of maternal PGS on child BMI, such that the influence of maternal genetic nurture appears to increase throughout development.

最近，引入了使用多基因评分 (PGS) 的方法来估计遗传培育的影响，即父母基因型对孩子表型的环境介导影响，超出了传递给孩子的等位基因的影响。我们引入了一个用于估计遗传培育效应的简化模型，并通过模拟和分析推导表明，我们的方法提供了无偏估计，并且比以前的方法检测遗传培育的能力提高了 1/3。随后，我们将这种方法应用于雅芳父母和儿童纵向研究的数据，以估计母亲遗传养育对儿童体重指数 (BMI) 轨迹的影响。通过混合造型，