Evolution of flow-oriented design strategies in the continuous preparation of pharmaceuticals,Reaction Chemistry & Engineering

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Evolution of flow-oriented design strategies in the continuous preparation of pharmaceuticals
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2020-07-17 , DOI: 10.1039/d0re00273a
Zsolt Fülöp _{1,

2,

3,

4} , Péter Szemesi _{1,

2,

3,

4} , Péter Bana _{4,

5,

6} , János Éles _{4,

5,

6} , István Greiner _{4,

5,

6}

Affiliation

The dynamic progress in the multi-step continuous-flow synthesis of active pharmaceutical ingredients is part of the current industrial revolution. The recently implemented examples are the forerunners of safer and more sustainable pharmaceutical manufacturing. These systems utilize interconnected flow apparatuses, integrated with in-line work-up, purification and analysis. Challenging targets call for customized, flow-oriented designs to establish novel, telescoped continuous-flow sequences. In this review we focus on these efforts towards the development of uninterrupted continuous-flow systems.

中文翻译：

药物连续制备中以流程为导向的设计策略的发展

活性药物成分的多步连续流合成中的动态进展是当前工业革命的一部分。最近实施的例子是更安全，更可持续的制药生产的先驱。这些系统利用相互连接的流动装置，并与在线后处理，纯化和分析集成在一起。具有挑战性的目标要求定制化的，面向流的设计，以建立新颖的，可伸缩的连续流序列。在本文中，我们将重点放在开发不间断连续流系统的这些努力上。

更新日期：2020-08-25

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