HIV-infected patients have immunological and clinical features that might affect the pathogenesis, as well as the outcome of the HIV/HEV co-infection. The current study aimed to determine the seroprevalence of anti-HEV antibodies and HEV antigens among HIV-infected patients in Fars Province, Southwest Iran. Blood samples (5 mL) were collected from 251 HIV-confirmed patients. Respective data, including patients’ demographic information, were obtained for each patient. The presence of HEV antigens and anti-HEV antibodies (IgG) were assessed by commercial ELISA kits, based on the manufacturers’ instructions. Out of 251 cases, 158 (62.9%) were male and 91 (36.3%) were female. Patients’ age varied from 14 to 83 (mean: 40 ± 9.7) years. Out of 251 HIV positive cases, 26 (10.4%) were positive for anti-HEV IgG antibodies and 6 (2.4%) were positive for HEV-antigens. Also, 2 (0.8%) of the patients were positive for both anti-HEV IgG antibodies and antigens. Statistical analysis revealed no significant association between sex and seropositivity to either HEV antigen or antibodies. Moreover, no significant association was seen between age and seropositivity to HEV antigen or antibody (P = 0.622 and 0.945, respectively). Our results showed a relatively low prevalence of HEV-antibodies in HIV-infected patients, indicating that HIV positive patients may not be at greater risk of HEV infection than the general population. Moreover, HEV-antigen was detected in a few cases of HIV-infected individuals which indicate an acute or chronic HEV infection in these patients.

中文翻译：

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伊朗南部法尔斯省艾滋病毒感染患者中抗戊型肝炎抗体和抗原的血清阳性率。

被HIV感染的患者具有可能影响其发病机理以及HIV / HEV合并感染结果的免疫学和临床特征。当前的研究旨在确定伊朗西南部Fars省HIV感染患者中抗HEV抗体和HEV抗原的血清阳性率。从251名HIV确诊患者中收集了血液样本（5 mL）。获得了每位患者的相应数据，包括患者的人口统计信息。HEV抗原和抗HEV抗体（IgG）的存在通过商业ELISA试剂盒根据制造商的说明进行评估。在251例病例中，男性158例（62.9％），女性91例（36.3％）。患者年龄从14岁到83岁（平均：40±9.7）岁。在251例HIV阳性病例中，有26例（10.4％）的抗HEV IgG抗体阳性，而6例（2。4％）的戊型肝炎病毒抗原呈阳性。另外，有2名（0.8％）患者的抗HEV IgG抗体和抗原均为阳性。统计分析表明，性别与对戊型肝炎病毒抗原或抗体的血清阳性之间没有显着关联。此外，在年龄和对戊型肝炎病毒抗原或抗体的血清阳性之间未发现显着相关性（分别为P = 0.622和0.945）。我们的结果表明，HIV感染患者中HEV抗体的患病率相对较低，表明HIV阳性患者的HEV感染风险可能不比普通人群高。此外，在少数HIV感染者中检测到HEV抗原，表明这些患者是急性或慢性HEV感染。统计分析表明，性别与对戊型肝炎病毒抗原或抗体的血清阳性之间没有显着关联。而且，在年龄和对戊型肝炎病毒抗原或抗体的血清阳性之间没有显着相关性（分别为P = 0.622和0.945）。我们的结果表明，HIV感染患者中HEV抗体的患病率相对较低，表明HIV阳性患者的HEV感染风险可能不比普通人群高。此外，在少数HIV感染者中检测到HEV抗原，表明这些患者是急性或慢性HEV感染。统计分析表明，性别与对戊型肝炎病毒抗原或抗体的血清阳性之间没有显着关联。而且，在年龄和对戊型肝炎病毒抗原或抗体的血清阳性之间没有显着相关性（分别为P = 0.622和0.945）。我们的结果表明，HIV感染患者中HEV抗体的患病率相对较低，表明HIV阳性患者的HEV感染风险可能不比普通人群高。此外，在少数HIV感染者中检测到HEV抗原，表明这些患者是急性或慢性HEV感染。分别）。我们的结果表明，HIV感染患者中HEV抗体的患病率相对较低，这表明HIV阳性患者的HEV感染风险可能不比一般人群高。此外，在少数HIV感染者中检测到HEV抗原，表明这些患者是急性或慢性HEV感染。分别）。我们的结果表明，HIV感染患者中HEV抗体的患病率相对较低，表明HIV阳性患者的HEV感染风险可能不比普通人群高。此外，在少数HIV感染者中检测到HEV抗原，表明这些患者是急性或慢性HEV感染。