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Exosome: a significant nano-scale drug delivery carrier.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-07-17 , DOI: 10.1039/d0tb01499k Huan Peng 1 , Weihong Ji , Ruichen Zhao , Jun Yang , Zhiguo Lu , Yan Li , Xin Zhang
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-07-17 , DOI: 10.1039/d0tb01499k Huan Peng 1 , Weihong Ji , Ruichen Zhao , Jun Yang , Zhiguo Lu , Yan Li , Xin Zhang
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In recent years, due to the limitations of the nature of therapeutic agents, many synthetic nano-delivery systems have emerged to enhance the efficacy of drugs. Extracellular vesicles are currently a class of natural nano-scale drug carriers released by cells. As a tiny vesicle with a lipid bilayer membrane that can be secreted by most cells in the body, exosomes carry and transmit important signal molecules, Therefore, they have been a research hotspot in biomedicine and biomaterials due to their size advantages and huge potential in drug therapy. Many people are optimistic about the clinical application prospects of exosomes and are actively exploring the broad functions of exosomes and developing exosome therapeutic agents to make positive contributions to human health. In this review, we provide basic knowledge and focus on summarizing the advantages of exosomes as drug carriers, methods of loading drugs, targeting strategies, in vivo and in vitro tracing methods, and some of the latest developments in exosomes as drug carriers. In particular, the review provides an outlook for this field.
中文翻译：
外泌体：重要的纳米级药物递送载体。
近年来，由于治疗剂的性质的局限性，出现了许多合成的纳米递送系统以增强药物的功效。细胞外囊泡目前是细胞释放的一类天然纳米级药物载体。外泌体是一种具有脂质双层膜的微小囊泡，可被体内大多数细胞分泌，它携带并传递重要的信号分子，因此，由于它们的体积优势和巨大的药物开发潜力，它们已成为生物医学和生物材料研究的热点。治疗。许多人对外泌体的临床应用前景感到乐观，并积极探索外泌体的广泛功能并开发外泌体治疗剂，以对人类健康做出积极贡献。在这篇评论中体内和体外示踪方法，以及作为药物载体的外泌体的一些最新进展。特别是，该评论提供了该领域的前景。
更新日期：2020-09-02
中文翻译：
外泌体：重要的纳米级药物递送载体。
近年来，由于治疗剂的性质的局限性，出现了许多合成的纳米递送系统以增强药物的功效。细胞外囊泡目前是细胞释放的一类天然纳米级药物载体。外泌体是一种具有脂质双层膜的微小囊泡，可被体内大多数细胞分泌，它携带并传递重要的信号分子，因此，由于它们的体积优势和巨大的药物开发潜力，它们已成为生物医学和生物材料研究的热点。治疗。许多人对外泌体的临床应用前景感到乐观，并积极探索外泌体的广泛功能并开发外泌体治疗剂，以对人类健康做出积极贡献。在这篇评论中体内和体外示踪方法，以及作为药物载体的外泌体的一些最新进展。特别是，该评论提供了该领域的前景。
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