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Near-infrared optically active Cu2-xS nanocrystals: sacrificial template-ligand exchange integration fabrication and chirality dependent autophagy effects.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-07-17 , DOI: 10.1039/d0tb01223h Yue Wang 1 , Yunsheng Xia
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-07-17 , DOI: 10.1039/d0tb01223h Yue Wang 1 , Yunsheng Xia
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We herein report a (sacrificial template-ligand exchange) integration strategy to fabricate near-infrared optically active Cu2−xS nanocrystals (NCs) and further investigate their interactions with cells, autophagy-induced tumor cell death, and photothermal ablation application potential. Starting from oleic acid capped Cu@Cu2−xO NCs, water-soluble and chiral D- and L-cysteine modified Cu2−xS (denoted as D-Cu2−xS and L-Cu2−xS, respectively) NCs have been reliably obtained by ligand exchange (from oleic acid to cysteine) accompanied by the core chemical transformation (from Cu@Cu2−xO to Cu2−xS). The resulting two enantiomeric Cu2−xS NCs have almost identical physicochemical properties including size, morphology, chemical composition, extinction band, peroxidase mimicking activity, and photothermal stability. The only exception is that the D- and L-Cu2−xS NCs exhibit mirror symmetric circular dichroism signals ranging from the ultraviolet to near-infrared region. The cellular uptake of the D-Cu2−xS NCs is about three times higher than that of their enantiomeric counterparts, which is likely attributed to their higher affinity with the cytomembranes of tumor cells (HepG2 and HeLa cells). As a result, a more prominent cellular autophagy proceeds due to the more significant production of highly reactive oxygen species. Then, the ablation of cells can be further enhanced by photothermal effects of the Cu2−xS NCs. Meanwhile, for normal cells, due to very limited cellular uptake effects, little cytotoxicity has been observed for both D- and L-Cu2−xS NCs.
中文翻译：
近红外旋光活性Cu2-xS纳米晶体：牺牲模板-配体交换集成制造和手性依赖自噬效应。
我们在此报告了一种（牺牲模板-配体交换）整合策略，以制造近红外旋光活性Cu 2- x S纳米晶体（NCs），并进一步研究其与细胞的相互作用，自噬诱导的肿瘤细胞死亡以及光热消融的应用潜力。从油酸封端的Cu @ Cu 2- x O NCs开始，水溶性和手性D-和L-半胱氨酸改性的Cu 2- x S（分别表示为D -Cu 2- x S和L -Cu 2- x通过配体交换（从油酸到半胱氨酸）伴随着核心化学转化（从Cu @ Cu 2- x O到Cu 2- x S）可靠地获得了NCs 。生成的两个对映体Cu 2- x S NC具有几乎相同的物理化学性质，包括大小，形态，化学组成，消光带，过氧化物酶模拟活性和光热稳定性。唯一的例外是D-和L -Cu 2- x S NC呈现出镜面对称的圆二色性信号，范围从紫外线到近红外区域。D -Cu 2- x的细胞摄取S NCs是其对映体对应物的三倍，这可能是由于它们与肿瘤细胞（HepG2和HeLa细胞）的细胞膜具有更高的亲和力。结果，由于更显着地产生高反应性氧，产生了更突出的细胞自噬。然后，细胞的消融可以通过Cu 2- x S NCs的光热效应进一步增强。同时，对于正常细胞，由于非常有限的细胞摄取作用，因此对于D-和L -Cu 2- x S NCs均未观察到细胞毒性。
更新日期：2020-09-16
中文翻译：
近红外旋光活性Cu2-xS纳米晶体：牺牲模板-配体交换集成制造和手性依赖自噬效应。
我们在此报告了一种（牺牲模板-配体交换）整合策略，以制造近红外旋光活性Cu 2- x S纳米晶体（NCs），并进一步研究其与细胞的相互作用，自噬诱导的肿瘤细胞死亡以及光热消融的应用潜力。从油酸封端的Cu @ Cu 2- x O NCs开始，水溶性和手性D-和L-半胱氨酸改性的Cu 2- x S（分别表示为D -Cu 2- x S和L -Cu 2- x通过配体交换（从油酸到半胱氨酸）伴随着核心化学转化（从Cu @ Cu 2- x O到Cu 2- x S）可靠地获得了NCs 。生成的两个对映体Cu 2- x S NC具有几乎相同的物理化学性质，包括大小，形态，化学组成，消光带，过氧化物酶模拟活性和光热稳定性。唯一的例外是D-和L -Cu 2- x S NC呈现出镜面对称的圆二色性信号，范围从紫外线到近红外区域。D -Cu 2- x的细胞摄取S NCs是其对映体对应物的三倍，这可能是由于它们与肿瘤细胞（HepG2和HeLa细胞）的细胞膜具有更高的亲和力。结果，由于更显着地产生高反应性氧，产生了更突出的细胞自噬。然后，细胞的消融可以通过Cu 2- x S NCs的光热效应进一步增强。同时，对于正常细胞，由于非常有限的细胞摄取作用，因此对于D-和L -Cu 2- x S NCs均未观察到细胞毒性。
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