Betanin is a phytocompound whose effect in steatohepatitis has not yet been tested. Betanin was extracted from the fruits of Hylocereus ocamponis, and its effects were evaluated in a mice model for non-alcoholic fatty liver disease. Six-week-old male BALB/c mice fed with a high-fat diet received 9.6 mg of betanin per day during 40 days. Body, liver, and epididymal fat pad weights and the levels of blood serum total cholesterol, triglycerides, high-density lipoproteins, alanine aminotransferase, blood nitrogen urea, creatinine, and total antioxidant capacity were measured. Hepatosteatosis and inflammatory infiltration were categorized, and the relative cell area of hepatocytes was determined. Betanin inhibited the inflammatory infiltration of the liver (P = 4.000 × 10⁻⁶) and the necrosis of hepatocytes (P = 9.634 × 10⁻⁷); it also produced a predominance of microvesicular steatosis (P = 9.634 × 10⁻⁷), decreased epididymal fat pad weight (P = 8.250 × 10⁻⁴), and increased blood serum total cholesterol (P = 0.011). Betanin is a promising compound for fatty liver, steatohepatitis, and chronic liver disease.

甜菜碱是一种植物化合物，其在脂肪性肝炎中的作用尚未得到验证。甜菜碱是从Hylocereus ocamponis的果实中提取的，并在非酒精性脂肪肝小鼠模型中评估了其作用。用高脂饮食喂养的六周大雄性BALB / c小鼠在40天内每天接受9.6 mg的甜菜碱。测量人体，肝脏和附睾脂肪垫的重量，以及血清总胆固醇，甘油三酸酯，高密度脂蛋白，丙氨酸氨基转移酶，血氮素，肌酐和总抗氧化剂的水平。肝脂肪变性和炎性浸润被分类，并测定肝细胞的相对细胞面积。甜菜碱抑制肝脏的炎症浸润（P = 4.000×10 ^-6）和肝细胞坏死（P = 9.634×10 ^-7）；它也引起微囊脂肪变性的盛行（P = 9.634×10 ^-7），附睾脂肪垫重量减少（P = 8.250×10 ^-4）和血清总胆固醇升高（P = 0.011）。甜菜碱是用于脂肪肝，脂肪性肝炎和慢性肝病的有前途的化合物。