The volatile constituents, toxicity, antinociception, and anti-inflammatory activities of the essential oil obtained from the leaf of Mucuna pruriens utilis collected from Nigeria are reported. The essential oil was analyzed comprehensively utilizing gas chromatography (GC)-flame ionization detector and GC coupled with mass spectrometry (MS) using the HP-5 column. The antinociceptive and anti-inflammatory assays were analyzed by a hot plate, formalin, and carrageenan-induced edema assays, respectively. The essential oil was obtained in a yield of 0.2% (v/w) calculated on a dry weight basis. A total of 36 compounds representing 94.8% of the oil contents were identified. The oil contained a high content of (E)-2-hexenal (19.0%), linalool (8.9%), 1-hexanol (6.6%), and trans-dehydroxylinalool oxide (5.2%). The analgesic property of the essential oil was slightly significant (P < 0.5) only at the third hour for the 400 mg/kg while other doses are less active. The rate of inhibition was moderate (24.1%-54%) during the analgesic phase of the formalin assay. The rate of inhibition at the anti-inflammatory phases of both formalin and carrageenan were significantly high (100%) and P < 0.001 for all the doses during the reaction duration. The potential proinflammatory mechanism might be due to effects on several proinflammatory mediators, including, histamine, serotonin, and bradykinin, and the ability of the essential oils to act as centrally mediated opioid analgesic. Mucuna pruriens essential oils displayed a high anti-inflammation potential and can be used as a potential centrally mediated opioid antagonist against analgesia.

据报道，从尼日利亚收集的毛util菜叶中获得的香精油的挥发性成分，毒性，抗伤害感受和抗炎活性。使用HP-5色谱柱，利用气相色谱（GC）-火焰电离检测器和GC结合质谱（MS）全面分析了香精油。通过热板，福尔马林和角叉菜胶诱导的水肿试验分别分析了抗伤害性和抗炎性试验。以干重计，以0.2％（v / w）的产率获得精油。共鉴定出36种化合物，占油含量的94.8％。该油含高含量的（E）-2-己烯（19.0％），芳樟醇（8.9％），1-己醇（6.6％）和反式-脱羟基芳樟醇氧化物（5.2％）。仅在第三个小时，对于400 mg / kg的精油，其镇痛特性略显显着（P <0.5），而其他剂量的镇痛效果则较差。在福尔马林测定的止痛阶段中，抑制率是中等的（24.1％-54％）。在反应期间，所有剂量的福尔马林和角叉菜胶在抗炎阶段的抑制率都很高（100％），P <0.001。潜在的促炎机制可能是由于对几种促炎介质（包括组胺，5-羟色胺和缓激肽）的影响，以及精油充当中枢介导的阿片类镇痛药的能力。毛uc 精油具有很高的抗发炎潜力，可以用作潜在的中枢介导的镇痛类阿片拮抗剂。