Polyketide synthases are multi-domain enzymes that catalyse the construction of many bioactive natural products. Now, some of the inefficiencies and limitations of these systems have been solved by designing an artificial pathway for carbon–carbon bond formation via iterative rounds of non-decarboxylative thio-Claisen reactions.

中文翻译：

---

聚酮化合物生物合成的人工途径

聚酮化合物合酶是多域酶，可催化许多生物活性天然产物的构建。现在，这些系统的一些效率低下和局限性已经通过为非脱羧硫代-克莱森反应的迭代回合设计了一条人工的碳-碳键形成途径而得以解决。