Abstract Candida species are fungal opportunistic pathogens capable of colonizing and infecting various human anatomical sites, where they have to adapt to distinct niche-specific pH conditions. The aim of this study was to analyse the features of Candida albicans and Candida glabrata biofilms developed under neutral and vaginal acidic (pH 4) conditions. C. albicans produced thicker and more filamentous biofilms under neutral than under acidic conditions. On the other hand, the formation of biofilms by C. glabrata was potentiated by the acidic conditions suggesting the high adaptability of this species to the vaginal environment. In general, both species developed biofilms containing higher amounts of matrix components (protein and carbohydrate) under neutral than acidic conditions, although the opposite result was found for one C. glabrata strain. Overall, this study contributes to a better understanding of the modulation of C. albicans and C. glabrata virulence by specific pH conditions.

中文翻译：

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环境 pH 调节白色念珠菌和光滑念珠菌的生物膜形成和基质组成

摘要 念珠菌属真菌机会性病原体，能够定植和感染各种人体解剖部位，在这些部位它们必须适应不同的生态位特定 pH 条件。本研究的目的是分析在中性和阴道酸性 (pH 4) 条件下形成的白色念珠菌和光滑念珠菌生物膜的特征。白色念珠菌在中性条件下比在酸性条件下产生更厚和更多的丝状生物膜。另一方面，C. glabrata 生物膜的形成被酸性条件加强，表明该物种对阴道环境的高度适应性。一般而言，两种物种在中性而非酸性条件下都形成了含有更多基质成分（蛋白质和碳水化合物）的生物膜，尽管在一种 C. glabrata 菌株中发现了相反的结果。